1-(4-(heptyloxy)phenyl)-3-(piperidin-1-yl)propan-1-one | 95000-40-1

• 英文名称: 1-(4-(heptyloxy)phenyl)-3-(piperidin-1-yl)propan-1-one
• 英文别名: 3-Piperidino-1-(4-heptyloxyphenyl)-propan-1-on；1-(4-Heptoxyphenyl)-3-piperidin-1-ylpropan-1-one
• CAS: 95000-40-1
• 化学式: C₂₁H₃₃NO₂
• 分子量: 331.499
• InChiKey: MGBSEAVFZLXRPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] 1-PHENYLPROPANONE COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS DE 1-PHÉNYLPROPANONE ET LEUR UTILISATION
  申请人：UNIV DEGLI STUDI PADOVA

  公开号：WO2018060947A1

  公开（公告）日：2018-04-05

  The present invention relates to a 1-phenylpropanone compound of formula (I), wherein X is CH2 or an atom selected from the group consisting of O, S and Se, n is an integer from 4 to 6, A is a substituent selected from the group consisting of 4-morpholyl, 1-piperidinyl, 4-methyl-1-piperazinyl, A being optionally substituted with a (C1-C3)alkyl or (C1-C3)acyl substituent, with the proviso that when X is CH2, n is equal to 5, for use as an antitumoral agent in the treatment of breast cancer, chronic lymphatic leukemia or neuroblastoma. The invention also concerns new 1-phenylpropanone compounds, and compounds as antitumoral agents.

  本发明涉及一种化合物，其化学式为(I)，其中X为CH2或从O、S和Se组成的原子中选择的一个，n为4到6之间的整数，A为从4-吗啡基、1-哌啶基、4-甲基-1-哌嗪基中选择的取代基，A可以选择地与(C1-C3)烷基或(C1-C3)酰基取代，但当X为 时，n等于5，用作抗肿瘤剂治疗乳腺癌、慢性淋巴细胞白血病或神经母细胞瘤。该发明还涉及新的1-苯基丙酮化合物，以及作为抗肿瘤剂的化合物。
• Anesthetic oral compositions
  申请人：Richardson-Vicks, Inc.

  公开号：EP0383481A2

  公开（公告）日：1990-08-22

  Disclosed are oral anesthetic pharmaceutical compositions compris­ing: (a) from about 0.02% to about 25% of a pharmaceutically accept­able acid salt of a β-aminopropiophenone, such as dyclonine HCl; (b) from about 0.02% to about 20% of saccharin; and (c) from about 1% to about 99% of a pharmaceutically acceptable oral carrier. Also provided are methods for providing an anesthetic effect in humans or animals which comprises orally administering to said human or animal a safe and effective amount of these pharmaceutical compositions. Also provided is a novel process for the manufacture of anesthetic lozenges contain­ing a β-aminopropiophenone along with saccharin.

  所公开的口服麻醉药物组合物包含：(a) 约 0.02% 至约 25% 的药学上可接受的 β-氨基苯丙酮酸盐，如盐酸地氯诺宁；(b) 约 0.02% 至约 20% 的糖精；以及 (c) 约 1% 至约 99% 的药学上可接受的口服载体。还提供了为人类或动物提供麻醉效果的方法，其中包括向所述人类或动物口服安全有效量的这些药物组合物。还提供了一种制造含有β-氨基苯丙酮和糖精的麻醉锭剂的新工艺。
• 1-phenylpropanone compounds and use thereof
  申请人：UNIVERSITA' DEGLI STUDI DI PADOVA

  公开号：US11345673B2

  公开（公告）日：2022-05-31

  The present invention relates to a 1-phenylpropanone compound of formula (I), wherein X is CH2 or an atom selected from the group consisting of O, S and Se, n is an integer from 4 to 6, A is a substituent selected from the group consisting of 4-morpholyl, 1-piperidinyl, 4-methyl-1-piperazinyl, A being optionally substituted with a (C1-C3)alkyl or (C1-C3)acyl substituent, with the proviso that when X is CH2, n is equal to 5, for use as an antitumoral agent in the treatment of breast cancer, chronic lymphatic leukemia or neuroblastoma. The invention also concerns new 1-phenylpropanone compounds, and compounds as antitumoral agents.

  本发明涉及式（I）的 1-苯基丙酮化合物，其中 X 是 CH2 或选自 O、S 和 Se 组成的组的原子，n 是 4 至 6 的整数，A 是选自 4-吗啉基、1-哌啶基、4-甲基-1-哌嗪基组成的组的取代基、4-甲基-1-哌嗪基，A任选被(C1-C3)烷基或(C1-C3)酰基取代，但当X为 时，n等于5，用作治疗乳腺癌、慢性淋巴性白血病或神经母细胞瘤的抗肿瘤剂。本发明还涉及新的 1-苯基丙酮化合物和作为抗肿瘤剂的化合物。
• 1-PHENYLPROPANONE COMPOUNDS AND USE THEREOF
  申请人：Universita' Degli Studi Di Padova

  公开号：EP3518927B1

  公开（公告）日：2020-08-12
• US4139627A
  申请人：——

  公开号：US4139627A

  公开（公告）日：1979-02-13