2-(4-chlorophenyl)-3-ferrocenylmethyl-1H-indole | 1283109-27-2

• 英文名称: 2-(4-chlorophenyl)-3-ferrocenylmethyl-1H-indole
• CAS: 1283109-27-2
• 化学式: C₂₅H₂₀ClFeN
• 分子量: 425.74
• InChiKey: CEJZBQWGNKMZBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  二茂铁甲醇 、 2-(4-氯苯基)吲哚 在 HBF₄ 作用下， 以 二氯甲烷 、 水 为溶剂， 以92%的产率得到2-(4-chlorophenyl)-3-ferrocenylmethyl-1H-indole
  参考文献：
  名称：

  Ferrocene–indole hybrids for cancer and malaria therapy

  摘要：

  We report the synthesis, characterization, and cytotoxic and antimalarial activity of ferrocene-indole hybrids 8-14. The 2-phenylindole scaffold was chosen because of its potent antimitotic activity and ferrocene was chosen following the development of ferrocifens, ferrocene derivatives of tamoxifen, which are prototypes of a new family of organometallic anti-estrogens. Ferrocene-indole hybrids 8-14 and their corresponding organic analogues 1-7 showed only moderate antimalarial activities, while ferrocene-indole hybrids 11 and 12 showed excellent in vitro activities against the A549 human carcinoma cell line, with IC50 values of 5 and 7 mu M respectively. These ferrocene-indole hybrids were up to 25-fold more potent as cytotoxic agents than their purely organic analogues. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2010.11.021