| 142904-21-0

• CAS: 142904-21-0；75659-38-0
• 化学式: C₅H₁₃ClN₅OPt
• 分子量: 389.724
• InChiKey: YSQVDHDIYGLEQG-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  盐酸 、 bis(μ-(1-methylcytosinato-N3,N4))-bis(cis-diammineplatinum(II))dinitrate 以 盐酸 为溶剂， 生成
  参考文献：
  名称：

  Diplatinum(III) complexes with bridging 1-methylcytosinate ligands and variable axial ligands, including guanine nucleobases

  摘要：

  A series of diplatinum(ill) complexes derived from cis-(NH3)(2)Pt" and the model nucleobase 1-methylcytosine (1-MeC) has been prepared and X-ray structurally characterized, all of which contain two anionic base ligands (1-MeC-) in a head-tail (ht).J2Pt(l_MeC -N3.JV4)2Pt(NH -HN0 ',.3H,O (2b), ht-cis+NO,) (NH,)2 Pt(l- arrangement: ht-cis+0NO,)(NH3 3)2(ONO,)](NO3)' MeC -N3,N4)(2)Pt(NH3)(2)(OH2)](ClO4)(3).3.5H(2)O (3), ht-cis-[(OH2)(NH3)(2)Pt(1-MeC-.N3,N4)(2)Pt(NH3)(2)(OH2)](ClO4)(4).H2O (4b), and ht-cis-[(9-EtGH-N7)(NH3)(2)Pt(1-MeC-.N3,N4)(2)Pt (NH3)(2)(9-EtGH-N7)](NO3)(4).9H(2)O (7b) (9-EtGH=9-ethylguanine). Several other compounds, differing in the nature of the axial ligands, have been isolated and or observed in solution by H-1 and Pt-195 NMR spectroscopy. The chemistry of these diplatinum(III) compounds is dominated by facile substitution reactions of the axial ligands. Of particular interest in this context is the ready reaction of 2b or 3 with guanine nucleobases. Since similar compounds are not obtained with any of the other common nucleobases, 2b and 3 can be considered guanine-specific chemical probes. C 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0020-1693(01)00741-1