Ru2(CO)4(μ²-η²-O2CC3H7)2(triphenylphosphine)2 | 228113-82-4

• 英文名称: Ru2(CO)4(μ²-η²-O2CC3H7)2(triphenylphosphine)2
• CAS: 228113-82-4
• 化学式: C₄₈H₄₄O₈P₂Ru₂
• 分子量: 1012.96
• InChiKey: UBOXQQVTIHAKJS-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  Ru2(μ-O2CH)2(CO)4(PPh3)2 、 正丁醇 以 甲苯 为溶剂， 以30%的产率得到Ru2(CO)4(μ²-η²-O2CC3H7)2(triphenylphosphine)2
  参考文献：
  名称：

  双核羧酸钌（I）配合物与醇的反应。伯醇意外氧化为羧基配体

  摘要：

  双核钌（I）配合物[Ru 2（HCO 2）2（CO）4（PPh 3）2 ]与伯醇R'CH 2 OH在回流的甲苯中反应，生成[Ru 2（R'CO 2）2（CO）4（PPh 3）2 ]化合物。其他羧酸盐桥接配合物与醇R''OH反应生成非常不稳定的醇盐化合物[Ru 2（R''O ）2（CO）4（PPh 3）2 ]。

  DOI：

  10.1016/s0022-328x(98)01131-0

文献信息

• Catalytic and anticancer activities of sawhorse-type diruthenium tetracarbonyl complexes derived from fluorinated fatty acids
  作者：Justin P. Johnpeter、Laurent Plasseraud、Frédéric Schmitt、Lucienne Juillerat-Jeanneret、Bruno Therrien

  DOI：10.1080/00958972.2013.790020

  日期：2013.5.1

  The reaction of fluorinated fatty acids, perfluorobutyric acid (C3F7CO2H), and perfluorododecanoic acid (C11F23CO2H), with dodecacarbonyltriruthenium (Ru-3(CO)(12)) under reflux in tetrahydrofuran, followed by addition of two-electron donors (L) such as pyridine, 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane, or triphenylphosphine, gives stable diruthenium complexes Ru-2(CO)(4)((2)-(2)-O2CC3F7)(2)(L)(2) (1a, L=C5H5N; 1b, L=PTA; 1c, L=PPh3) and Ru-2(CO)(4)((2)-(2)-O2CC11F23)(2)(L)(2) (2a, L=C5H5N; 2b, L=PTA; 2c, L=PPh3). The catalytic activity of the complexes for hydrogenation of styrene under supercritical carbon dioxide has been assessed and compared to the analogous triphenylphosphine complexes with non-fluorinated carboxylato groups Ru-2(CO)(4)((2)-(2)-O2CC3H7)(2)(PPh3)(2) (3) and Ru-2(CO)(4)((2)-(2)-O2CC11H23)(2)(PPh3)(2) (4). In addition, the cytotoxicities of the fluorinated complexes 1 were also evaluated on several human cancer cell lines (A2780, A549, Me300, HeLa). The complexes appear to be moderately cytotoxic, showing greater activity on the Me300 melanoma cells. Single-crystal X-ray structure analyses of 1a and 3 show the typical sawhorse-type arrangement of the diruthenium tetracarbonyl backbone with two bridging carboxylates and two terminal ligands occupying the axial positions.