4-(4-isopropyl-piperazin-1-yl)-3-trifluoromethyl-phenylamine | 915020-77-8

• 英文名称: 4-(4-isopropyl-piperazin-1-yl)-3-trifluoromethyl-phenylamine
• 英文别名: 4-(4-Isopropylpiperazin-1-yl)-3-(trifluoromethyl)phenylamine；4-(4-propan-2-ylpiperazin-1-yl)-3-(trifluoromethyl)aniline
• CAS: 915020-77-8
• 化学式: C₁₄H₂₀F₃N₃
• 分子量: 287.328
• InChiKey: IOPWDADEQVPJOS-UHFFFAOYSA-N

物化性质

• 沸点：
  377.9±42.0 °C(Predicted)
• 密度：
  1.193±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  32.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-{8-[4-(1-isopropylpiperidin-4-yl)phenylamino]-imidazo[1,2-a]pyrazin-5-yl}-2,3-dihydroisoindol-1-one 、 4-(4-isopropyl-piperazin-1-yl)-3-trifluoromethyl-phenylamine 生成 5-{8-[4-(4-isopropylpiperazin-1-yl)-3-trifluoromethylphenylamino]imidazo[1,2-a]pyrazin-5-yl}-2,3-dihydroisoindol-1-one
  参考文献：
  名称：

  Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases

  摘要：

  本发明揭示了具有以下公式表示的新型咪唑并[1,2-a]吡嗪化合物：这些化合物可以制备为药物组合物，并可用于预防和治疗哺乳动物，包括人类的多种疾病，例如关节炎，炎症等。

  公开号：

  US07893058B2

文献信息

• 1,3-Dihydro-Imidazo [4,5-C] Quinolin-2-Ones as Lipid Kinase Inhibitors
  申请人：Garcia-Echeverria Carlos

  公开号：US20080194579A1

  公开（公告）日：2008-08-14

  The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.

  本发明涉及公式（I）的新有机化合物，其制备方法，其在治疗人体或动物的过程中的应用，其单独或与一种或多种其他药物活性化合物结合使用，用于治疗炎症或阻塞性呼吸道疾病，如哮喘，与移植相关的常见疾病或增生性疾病，如肿瘤疾病。
• Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases
  申请人：Edwards Paul John

  公开号：US20090048245A1

  公开（公告）日：2009-02-19

  Novel imidazolopyridine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.

  本发明揭示了一种具有以下公式表示的新型咪唑吡啶化合物：这些化合物可以制备为药物组合物，并可用于预防和治疗哺乳动物，包括人类的多种病症，包括但不限于ECM降解、关节降解和/或炎症等。
• 1,3-DIHYDRO-IMIDAZO[4,5-C]QUINOLIN-2-ONES AS LIPID KINASE INHIBITORS
  申请人：Garcia-Echeverria Carlos

  公开号：US20100056558A1

  公开（公告）日：2010-03-04

  The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.

  本发明涉及公式（I）的新有机化合物，其制备方法，其在处理人或动物体的过程中的应用，其单独使用或与一个或多个其他药物活性化合物结合使用，用于治疗炎症或阻塞性呼吸道疾病，如哮喘，与移植有关的常见疾病或增生性疾病，如肿瘤疾病。
• IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
  申请人：Andrews Martin James Inglis

  公开号：US20110092497A1

  公开（公告）日：2011-04-21

  Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

  公开了一种具有以下公式表示的新型咪唑并[1,2-a]吡嗪化合物：这些化合物可以制备为药物组合物，并可用于预防和治疗哺乳动物包括人类的各种疾病，包括但不限于关节炎，炎症等。
• Imidazoquinolines as lipid kinase inhibitors
  申请人：Garcia-Echeverria Carlos

  公开号：US20120207751A1

  公开（公告）日：2012-08-16

  The invention relates to a combination comprising compounds of formula (I) and one or more other antiproliferative compounds, hormones or radiation, pharmaceutical preparations comprising the combination thereof, and the application thereof in a process for the treatment of tumors.

  本发明涉及一种组合物，包括式(I)的化合物和一种或多种其他抗增殖化合物、激素或辐射，以及包含该组合物的药物制剂，以及其在肿瘤治疗过程中的应用。