1-Chloro-4-isocyanobutane | 328898-37-9

• 英文名称: 1-Chloro-4-isocyanobutane
• CAS: 328898-37-9
• 化学式: C₅H₈ClN
• 分子量: 117.578
• InChiKey: PLPBDOJOXDDZFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  4.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  [RuCl2(hexamethylbenzene)]2 、 1-Chloro-4-isocyanobutane 以 二氯甲烷 为溶剂， 以66%的产率得到
  参考文献：
  名称：

  Isocyanide arene-ruthenium(II) complexes and activation of alkenylacetylenes: synthesis and characterization of isocyanide carbene- and mixed carbene-ruthenium compounds

  摘要：

  [RuCl2(eta-6-arene)]2 complexes 1 (eta-6-MeC6H4(i)Pr), 2 (eta-6-C6H2Me4), and 3 (eta-6-C6Me6) react with isocyanide CNR [R = (t)Bu (a), C6H11 (b), CH2CO2C6H4Me (c), CH2CO2Et (d), (CH2)4Cl (e), and (CH2)2OSiMe3 (f)] to produce a variety of RUCl2(CNR)(eta-6-arene) derivatives 4-6, which give a C = N absorption in the infrared at high wavenumbers between 2165 and 2206 cm-1. (C6Me6)Cl2RuCN(CH2)2OSiMe3 (6f) on reaction with KF in methanol affords the carbene complex (C6Me6)Cl2Ru:CNHCH2CH2O (8). Cyclic voltammetry of complexes 4-6 shows that only with the most electron-releasing arene C6Me6 a reversible oxidation occurs, at 1.06-1.15 V(SCE) for complexes 6a-f and at 0.80 V(SCE) for 8. Complexes 6a, 6e, and 8 activate isopropenylacetylene, via an allenylidene intermediate, and in the presence of methanol give access to alkenylcarbene complexes containing the Ru = C(OMe)CH = CMe2 moiety 7a,e and the mixed carbene complex 9.

  DOI：

  10.1021/om00055a055

文献信息

• New C-tetrazolato complexes of rhodium(III), palladium(II) and gold(III)
  作者：Martin Wehlan、Renate Thiel、Joachim Fuchs、Wolfgang Beck、Wolf Peter Fehlhammer

  DOI：10.1016/s0022-328x(00)00457-5

  日期：2000.11

  The azido complexes [RhCp*(μ-N3)(N3)]2 (Cp*=η-C5Me5), trans-Rh(N3)(CO)(PPh3)2, Na2[Pd(N3)4], Na2[Pd2(μ-N3)2(N3)4] and Na[Au(N3)4], prepared in situ from metal halide precursors and a three- to ten-fold excess of NaN3 in water, react with aliphatic isocyanides to give a series of new metal–carbon bonded tetrazolato complexes. All azide ligands in the coordination sphere undergo this cycloaddition with

  叠氮基配合物[RHCP *（μ-N 3）（N 3）] 2（CP * =η-C 5我5），反式-Rh（N 3）（CO）（PPH 3）2，钠2 [钯（N 3）4 ]，钠2 [的Pd 2（μ-N 3）2（N 3）4 ]和Na [金（N 3）4 ]，从金属卤化物前体和三到ten-原位制备NaN 3过量倍数在水中，与脂族异氰酸酯反应生成一系列新的金属-碳键合的四唑并合物。配位域中的所有叠氮化物配体都与异氰酸酯进行这种环加成反应，但钯（II）上仅形成两个四唑-5-ato基。在中性物质HAu（CN 4 R）4（R = t Bu（2c），Cy（2d））中，大概四个四唑-5-ato基团中的一个已质子化，从而得到四唑-5-亚烷基（卡宾）配体。异氰酸酯的反应性按CN t Bu> CNCy> CN（CH 2）4 Cl> CN-烯丙基> CNCH 2 CO 2的顺序降低娜 令人惊讶地，没有与甲基异氰发生反应。与叔丁基异氰化物在寒冷，的[Ru（μ-N
• Analogues of cilostazol
  申请人：Liu Julie F.

  公开号：US20090042842A1

  公开（公告）日：2009-02-12

  This invention relates to novel compounds which are derivatives of the phosphodiesterase inhibitor, cilostazol and pharmaceutically acceptable salts thereof. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administration of an phosphodiesterase inhibitor, such as cilostazol. The invention also relates to the use of the disclosed compounds and compositions as reagents in analytical studies involving cilostazol.
• ANALOGUES OF CILOSTAZOL
  申请人：Persichetti Rose A.

  公开号：US20100249079A1

  公开（公告）日：2010-09-30

  This invention relates to novel compounds which are derivatives of the phosphodiesterase inhibitor, cilostazol and pharmaceutically acceptable salts thereof. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administration of a phosphodiesterase inhibitor, such as cilostazol. The invention also relates to the use of the disclosed compounds and compositions as reagents in analytical studies involving cilostazol.
• US8349817B2
  申请人：——

  公开号：US8349817B2

  公开（公告）日：2013-01-08
• US8357674B2
  申请人：——

  公开号：US8357674B2

  公开（公告）日：2013-01-22