| 1339873-07-2

• CAS: 1339873-07-2
• 化学式: C₁₄H₁₁NO₇Tc
• 分子量: 404.244
• InChiKey: SXRRRHNOYCFUBS-RCUQKECRSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  fac-triaquatricarbonyltechnetium-99m(1+) 、 dimethyl N-benzyliminodiacetate 在 HCl 作用下， 以 甲醇 、 水 为溶剂， 以78.6%的产率得到
  参考文献：
  名称：

  Effective synthesis of 99mTc tricarbonyl complexes by microwave heating

  摘要：

  Technetium-99m (Tc-99m) is one of the most frequently used nuclides for single-photon emission computed tomography (SPECT) imaging because of its radiochemical characteristics, such as gamma emission of suitable energy (141 keV) and adequate half-life (6.01 h). Although triaquatricarbonyl Tc-99m cation ([Tc-99m(CO)(3)(H2O)(3)](+)) has several advantages as a Tc-99m-labeling agent, e.g., compact chelate size, chelate stability, and simplicity of preparation, its synthetic protocols should be improved. Because microwave heating is a convenient method for synthetic reactions, we studied the effect of microwave irradiation on the synthesis of Tc-99m tricarbonyl complexes. We found several factors beneficial for the preparation of nuclear medicines. In particular, microwave heating promoted one-pot syntheses of Tc-99m tricarbonyl chelates in a short time. In addition, the Tc-99m tricarbonyl complex could be obtained using low concentrations of ligands. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2011.08.033