dichloro-[3-acetoxymethyl-7-bromo-1,3-dihydro-1-methyl-5-(2'-pyridyl)-2H-1,4-benzodiazepin-2-one-N,N]palladium(II) | 502963-04-4

• 英文名称: dichloro-[3-acetoxymethyl-7-bromo-1,3-dihydro-1-methyl-5-(2'-pyridyl)-2H-1,4-benzodiazepin-2-one-N,N]palladium(II)
• CAS: 502963-04-4
• 化学式: C₁₈H₁₆BrCl₂N₃O₃Pd
• 分子量: 579.573
• InChiKey: PXPHCZUQOOYXEF-HKPSJHCMSA-L

反应信息

• 作为产物：
  描述：

  sodium tetrachloropalladate(II) trihydrate 、 rac-3-acetoxymethyl-7-bromo-2,3-dihydro-1-methyl-5-(2'-pyridyl)-2H-1,4-benzodiazepin-2-one 以 甲醇 、 二氯甲烷 为溶剂， 以80%的产率得到dichloro-[3-acetoxymethyl-7-bromo-1,3-dihydro-1-methyl-5-(2'-pyridyl)-2H-1,4-benzodiazepin-2-one-N,N]palladium(II)
  参考文献：
  名称：

  Synthesis, structural characterisation and biological activity of Zn(II) and Pd(II) complexes of 3-substituted 5-(2′-pyridyl)-1,4-benzodiazepin-2-one derivatives

  摘要：

  Zn-II and Pd-II complexes of 7-bromo-1,3-dihydro-3-hydroxymethyl-1-methyl-5-(2'-pyridyl)-2H-1,4-benzodiazepin-2-one ((+)-L1), and 3-acetoxymethyl-7-bromo-1,3-dihydro-1-methyl-5-(2'-pyridyl)-2H-1,4-benzodiazepin-2-one ((+/-)-L2) were prepared and determined by spectroscopic studies (IR and H-1 NMR) and X-ray structure analysis. The influence of the metal coordination on the absolute configuration at the stereogenic centre of the chiral ligands was studied. In ZnL1Cl(2) (1) a distorted trigonal bipyramid was formed in which L1 acts as a tridentate N,N,O-Iigand, while in the case of ZnL2Cl(2) (3), Zn-II is in a distorted tetrahedral environment coordinated by two azomethine nitrogen and two chlorine atoms. Zn-II complexes 1 and 3 are the first zinc complexes of benzodiazepines reported so far. In Pd-II complexes 2 and 4, the expected square-planar coordination was observed. The free ligands and their complexes were evaluated for their in vitro cytostatic activity against the murine L1210/0 and human T-lymphoblast Molt/ C8 and CEM/0 cell lines, as well as for their in vitro-antiviral activity in different assay systems. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0277-5387(02)01251-2