tert-butyl N-[2-(2-bromophenoxy)ethyl]-N-[pyridin-4-ylmethyl]carbamate | 727742-13-4

• 英文名称: tert-butyl N-[2-(2-bromophenoxy)ethyl]-N-[pyridin-4-ylmethyl]carbamate
• 英文别名: tert-butyl N-[2-(2-bromophenoxy)ethyl]-N-(pyridin-4-ylmethyl)carbamate
• CAS: 727742-13-4
• 化学式: C₁₉H₂₃BrN₂O₃
• 分子量: 407.307
• InChiKey: OFFQWEUMXQTVJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  51.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] THIOPHENE CARBOXAMIDES AS INHIBITORS OF THE ENZYME IKK-2<br/>[FR] THIOPHENE CARBOXAMIDES UTILISES EN TANT QU'INHIBITEURS DE L'ENZYME IKK-2
  申请人：ASTRAZENECA AB

  公开号：WO2004063185A1

  公开（公告）日：2004-07-29

  The invention relates to thiophene carboxamides of formula (I) wherein Ar, R1, R2, R3, R4, R5, m and n are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

  这项发明涉及到式(I)的噻吩羧酰胺，其中Ar、R1、R2、R3、R4、R5、m和n如规范中所定义，以及用于它们制备的工艺和中间体，含有它们的药物组合物以及它们在治疗中的应用。
• Thiophene carboxanmides as inhibitors of the enzyme ikk-2
  申请人：Morley David Andrew

  公开号：US20060111431A1

  公开（公告）日：2006-05-25

  The invention relates to thiophene carboxamides of formula (I) wherein Ar, R1, R2, R3, R4, R5, m and n are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明涉及公式(I)的噻吩羧酰胺，其中Ar，R1，R2，R3，R4，R5，m和n如规范中所定义，以及用于它们的制备的过程和中间体，含有它们的制药组合物以及它们在治疗中的用途。
• THIOPHENE CARBOXAMIDES AS INHIBITORS OF THE ENZYME IKK-2
  申请人：Morley Andrew David

  公开号：US20090215829A1

  公开（公告）日：2009-08-27

  The invention relates to thiophene carboxamides of formula (I), wherein Ar, R 1 , R 2 , R 3 , R 4 , R 5 , m and n are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明涉及式(I)的噻吩羧酰胺，其中Ar、R1、R2、R3、R4、R5、m和n如规范中所定义，以及用于它们制备的过程和中间体，含有它们的制药组合物以及它们在治疗中的应用。
• US7553868B2
  申请人：——

  公开号：US7553868B2

  公开（公告）日：2009-06-30