N-t-butyl-4-(4-acetylphenylthio)aniline | 156813-53-5

• 英文名称: N-t-butyl-4-(4-acetylphenylthio)aniline
• 英文别名: 1-[4-[4-(Tert-butylamino)phenyl]sulfanylphenyl]ethanone
• CAS: 156813-53-5
• 化学式: C₁₈H₂₁NOS
• 分子量: 299.437
• InChiKey: LADLBWFGVUANGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• N-t-BUTYLANILINE ANALOG AND LIPID LEVEL DEPRESSANT CONTAINING THE SAME
  申请人：TAISHO PHARMACEUTICAL CO. LTD

  公开号：EP0666253A1

  公开（公告）日：1995-08-09

  An N-t-butylaniline analog represented by general formula (I) or a salt thereof, and a lipid level depressant containing the same as the active ingredient. In said formula, R¹ and R², which may be the same or different from each other, represent each hydrogen, halogen, amino, nitro, acetamide, lower alkyl, lower alkoxy, halogenated lower alkyl, halogenated lower alkoxy or lower alkanoyl; R³ represents hydrogen, halogen, lower alkoxy or halogenated lower alkyl; and Z represents S, SO or SO₂. This compound has a remarkably excellent effect of depressing the lipid level as compared with clofibrate and 4-(N-t-butyl)methanesulfonylaminodiphenyl ether and is extremely reduced in toxicity.

  一种由通式(I)代表的N-叔丁基苯胺类似物或其盐，以及一种含有相同活性成分的血脂水平抑制剂。在所述通式中，R¹和R²可以相同或不同，分别代表氢、卤素、氨基、硝基、乙酰胺、低级烷基、低级烷氧基、卤代低级烷基、卤代低级烷氧基或低级烷酰基；R³代表氢、卤素、低级烷氧基或卤代低级烷基；Z代表S、SO或SO₂。与氯贝特和 4-(N-叔丁基)甲磺酰氨基二苯醚相比，这种化合物具有显著的降脂效果，而且毒性极低。