(η6-C6H6)RuCl[(C6H5)NC(CH3)]2CH | 1204766-51-7

• 英文名称: (η6-C6H6)RuCl[(C6H5)NC(CH3)]2CH
• CAS: 1204766-51-7
• 化学式: C₂₃H₂₃ClN₂Ru
• 分子量: 463.972
• InChiKey: FLXWHMNDGCFHQU-JWRHQXMQSA-M

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  [RuCl2(benzene)]2 、 Li[(C6H5)NC(CH3)]2CH 以 二氯甲烷 为溶剂， 以67.3%的产率得到(η6-C6H6)RuCl[(C6H5)NC(CH3)]2CH
  参考文献：
  名称：

  Rational Design of Highly Cytotoxic η⁶-Arene β-Diketiminato−Ruthenium Complexes

  摘要：

  A series of ruthenium-benzene complexes with beta-diketiminate ligands modified with electron-withdrawing groups were prepared and characterized by NMR spectroscopy, Mass spectrometry, and single-crystal X-ray diffraction. The complexes are stable in air and Undergo controlled hydrolysis in water. The complexes were evaluated for anticancer activity in vitro, and two of them proved to be highly cytotoxic, comparable or even superior to cisplatin. This work shows the potential utility of the beta-diketiminate ligand in the rational design of new anticancer metal-containing drugs. A related complex with a eta(6)-C6H5CF3 ligand was prepared and found to undergo a nucleophilic addition reaction at the coordinated arene ring to afford a Substituted eta(5)-cyclohexadienyl derivative.

  DOI：

  10.1021/om900991b