cis-ammine(3-amino-2,2,5,5-tetramethylpyrrolidin-1-oxyl)dichloroplatinum (II) | 325139-45-5

• 英文名称: cis-ammine(3-amino-2,2,5,5-tetramethylpyrrolidin-1-oxyl)dichloroplatinum (II)
• 英文别名: cis-ammine(3-amino-2,2,5,5-tetramethylpyrrolidine-1-oxyl)dichloroplatinum(II)
• CAS: 325139-45-5
• 化学式: C₈H₂₀Cl₂N₃OPt
• 分子量: 440.252
• InChiKey: NNQNAFBTVYCHEG-MAJYTBHHSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  cis-ammine(3-amino-2,2,5,5-tetramethylpyrrolidin-1-oxyl)dichloroplatinum (II) 在 potassium tungstate H₂O₂ 作用下， 以 乙醇 、 水 为溶剂， 以79%的产率得到e-ammine-d-(3-amino-2,2,5,5-tetramethylpyrrolidine-1-oxyl)-a,f-dihydroxo-b,c-dichloroplatinum(II)
  参考文献：
  名称：

  摘要：

  The platinum(IV) complexes cis,trans,cis-Pt-IV(RNH2)(NH3)(OH)(2)Cl-2, where R is 2,2,6,6-tetramethyl-1-oxyl-4-piperidinyl (1) or 2,2,5,5-tetramethyl-1-oxyl-3-pyrrolidinyl (2), were prepared by oxidation of the corresponding cis-Pt-II(RNH2)(NH3)Cl-2 complexes with hydrogen peroxide. The reactions are catalyzed by tungstate salts, which makes it possible to carry out oxidation under mild conditions. The resulting complexes were characterized by elemental analysis, HPLC, and IR, UV, and ESR spectroscopy. The structure of complex 1 was established by X-ray diffraction analysis. Complex 1 exhibits the highest antitumor activity in an experimental tumor, viz., in P388 leukemia. The resistance of the tumor to this complex developed much slower than that to Cisplatin.

  DOI：

  10.1023/a:1023475319835
• 作为产物：
  描述：

  3-氨基-2,2,5,5-四甲基-1-吡咯烷酮 在 AgNO₃ 作用下， 以 水 为溶剂， 生成 cis-ammine(3-amino-2,2,5,5-tetramethylpyrrolidin-1-oxyl)dichloroplatinum (II)
  参考文献：
  名称：

  Synthesis, structure, and biological activity of mixed-ligand platinum(II) complexes with aminonitroxides

  摘要：

  Mixed-ligand platinum complexes cis-Pt-11((RNH2)-N-6)(NH3)X-2 and cis-Pt-11((RNH2)-N-5)(NH3)X-2 (R-6 is 2,2,6,6-tetramethyl-4-piperidyl-1-oxyl and R-5 is 2,2,5,5-tetramethyl-3-pyrrolidinyl-1-oxyl) were synthesized by either the reaction of aminonitroxides RNH2 with Na[Pt-11(NH3)CI2I] generated in situ (for X-2 = ClI) or by replacement of the iodo-chloro ligands in Cis-Pt-11(RNH2)(NH3)Cll by dichloro and oxalato ligands. The complexes obtained were characterized by elemental analysis and by IR, UV, and ESR spectra. For Cis-Pt-11((RNH2)-N-5)(NH3)Cl-2, crystal and molecular structures were determined by X-ray diffraction analysis. Cisplatin accelerates autooxidation of methyl linoleate and the platinum nitroxide complexes synthesized exhibit antioxidant properties. The rate of isolated DNA binding with the new complexes is almost as high as that for cisplatin. cis-Pt-11((RNH2)-N-6)(NH3)Cl-2 exhibits the highest antitumor activity. The high antitumor activity of platinum nitroxide complexes shows that the possible "radical component" is not a crucial factor in the cytotoxic action of cisplatin.

  DOI：

  10.1007/bf02495168