Ir(1,5-cyclooctadiene)Cl(chloroquine) | 947503-76-6

• 英文名称: Ir(1,5-cyclooctadiene)Cl(chloroquine)
• 英文别名: Ir(COD)Cl(CQ)
• CAS: 947503-76-6
• 化学式: C₂₆H₃₈Cl₂IrN₃
• 分子量: 655.734
• InChiKey: OFZXXFLNKNVQCK-RBCKLSLESA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  bis(1,5-cyclooctadiene)diiridium(I) dichloride 、 氯喹 以 乙醇 为溶剂， 以63%的产率得到Ir(1,5-cyclooctadiene)Cl(chloroquine)
  参考文献：
  名称：

  Synthesis, characterization and antimalarial activity of new iridium–chloroquine complexes

  摘要：

  Chloroquine base (CQ) reacts with [Ir(COD)Cl](2) and IrCl3 center dot 3H2O to yield of Ir(CQ)Cl(COD) (1) and Ir2Cl6(CQ) center dot 3H2O (2), respectively. Reaction of [Ir(C0D)Cl](2)with CQ in the presence of NH4PF6 leaded to [Ir(CQ)(Solv)(2)]PF6 (3). The three new iridium-CQ complexes were characterized by a combination of elemental analysis, IR and NMR spectroscopies and evaluated in vitro against Plasmodium beghei. Comparison of the IC50 values obtained with the experimental compounds with that determined for chloroquine diphosphate indicated a higher activity for complex 2, while complexes 1 and 3 showed a similar and lower activity, respectively. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2006.12.010