[Pd2{(C,N)C6H4CH2NH(Et)}2(μ-Br)2] | 1565761-70-7

• 英文名称: [Pd2{(C,N)C6H4CH2NH(Et)}2(μ-Br)2]
• 英文别名: [Pd₂{(C,N)C₆H₄CH₂NH(Et)}₂(μ-Br)2]
• CAS: 1565761-70-7
• 化学式: C₁₈H₂₄Br₂N₂Pd₂
• 分子量: 641.05
• InChiKey: CNVBDUVHTAPZQS-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  [Pd2{(C,N)C6H4CH2NH(Et)}2(μ-Br)2] 、 1,2-双(二苯基膦)乙烷 以 二氯甲烷 为溶剂， 反应 2.0h， 以87%的产率得到[Pd₂{(C,N)-C₆H₄CH₂NH(Et)}₂(μ-dppe)(Br)₂]
  参考文献：
  名称：

  In vitro cytotoxicity studies of palladacyclic complexes containing the symmetric diphosphine bridging ligand. Studies of their interactions with DNA and BSA

  摘要：

  The reactions between [Pd-2{(C,N)-C6H4CH2NH(Et)}(2)(mu-X)(2)] (X = Cl or Br) and 1,2-bis(diphenylphosphino)ethane (dppe) in the 1:1 molar ratio resulted in the dppe-bridged Pd(II) complexes, [Pd-2{(C,N)-C6H4CH2NH(Et)}(2)(mu-dPPe)(Cl)(2)] (1) and [Pd-2{(C,N)-C6H4CH2NH(Et)}(2)(mu-dPPe)(Br)(2)] (2), respectively, which were characterized by elemental analyses, infrared (IR), H-1- and P-31{H-1} NMR spectroscopy. The molecular structure of I was determined by single-crystal X-ray diffraction. In vitro cytotoxicity of 1, 2, dppe, PhCH2NH(Et) and cisplatin were carried out against four human tumor cell lines. The interactions of complexes towards DNA and protein are investigated. The results suggested that both complexes could interact with FS-DNA through the intercalation mode. Moreover, the reactivity towards BSA revealed that the microenvironment and the secondary structure of BSA were changed in the presence of Pd(II) complexes. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.11.042