9-butyl-6-(5-methyl-[1,1'-biphenyl]-2-yl)-9H-purine | 1284287-17-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 9-butyl-6-(5-methyl-[1,1'-biphenyl]-2-yl)-9H-purine
• CAS: 1284287-17-7
• 化学式: C₂₂H₂₂N₄
• 分子量: 342.443
• InChiKey: HQBOLJHSJVZYFK-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  碘苯 、 6-(4-methylphenyl)-9-butylpurine 在 silver(I) acetate 、 palladium diacetate 、 溶剂黄146 作用下， 反应 60.0h， 以85%的产率得到9-butyl-6-(5-methyl-[1,1'-biphenyl]-2-yl)-9H-purine
  参考文献：
  名称：

  Pd(II)-Catalyzed Ortho Arylation of 6-Arylpurines with Aryl Iodides via Purine-Directed C−H Activation: A New Strategy for Modification of 6-Arylpurine Derivatives

  摘要：

  Purine is utilized as a new directing group for the Pd-catalyzed monoarylation of 6-arylpurines with simple aryl iodides via C H bond activation in good yields, providing a complementary tool for the modification of 6-arylpurines (nucleosides). Most importantly, purine can be used as a building block for nucleoside derivatives, and the use of purine as a directing group helps avoid additional synthetic steps.

  DOI：

  10.1021/ol200405w