Zn(2-((2-(piperazin-1-yl)ethylimino)methyl)-4-bromophenol)Cl2 | 1421678-27-4

• 英文名称: Zn(2-((2-(piperazin-1-yl)ethylimino)methyl)-4-bromophenol)Cl2
• CAS: 1421678-27-4；1574323-19-5
• 化学式: C₁₃H₁₇BrCl₂N₃OZn*H
• 分子量: 448.505
• InChiKey: MNGNHRNEPDMTPE-LSCKKZOKSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  2-((2-(piperazin-1-yl)ethylimino)methyl)-4-bromophenol 、 zinc(II) chloride 以 甲醇 为溶剂， 反应 8.0h， 以83.1%的产率得到Zn(2-((2-(piperazin-1-yl)ethylimino)methyl)-4-bromophenol)Cl2
  参考文献：
  名称：

  Mononuclear zinc(II) complexes of 2-((2-(piperazin-1-yl)ethylimino)methyl)-4-substituted phenols: Synthesis, structural characterization, DNA binding and cheminuclease activities

  摘要：

  Four new new zinc(II) complexes [Zn(HL1-4)Cl-2] (1-4), where HL1-4 = 2-((2-(piperazin-1-yl)ethylimino)methyl)-4-substituted phenols, have been isolated and fully characterized using various spectro-analytical techniques. The X-ray crystal structure of complex 4 shows the distorted trigonal-bipyramidal coordination geometry around zinc(II) ion. The crystal packing is stabilized by intermolecular N-H center dot center dot center dot O hydrogen bonding interaction. The complexes display no d-d electronic band in the visible region due to d(10) electronic configuration of zinc(II) ion. The electrochemical properties of the synthesized ligands and their complexes exhibit similar voltammogram at reduction potential due to electrochemically innocent Zn(II) ion, which evidenced that the electron transfer is due to the nature of the ligand. Binding interaction of complexes with calf thymus DNA was studied by UV-Vis absorption titration, viscometric titration and cyclic voltammetry. All complexes bind with CT DNA by intercalation, giving the binding affinity in the order of 2 > 1 >> 3 > 4. The prominent cheminuclease activity of complexes on plasmid DNA (pBR322 DNA) was observed in the absence and presence of H2O2. Oxidative pathway reveals that the underlying mechanism involves hydroxyl radical. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2014.01.026