[(N-phenyl-pyridylmethylideneamino)ZnCl2] | 865061-22-9

• 英文名称: [(N-phenyl-pyridylmethylideneamino)ZnCl2]
• 英文别名: N-phenyl-1-(pyridin-2-yl)methanimine(dichloro)zinc(II)；N-phenyl-(pyridin-2-yl)methanimine(ZnCl₂)；[Zn(N-(pyridin-2-ylmethylene)aniline)Cl2]
• CAS: 865061-22-9
• 化学式: C₁₂H₁₀Cl₂N₂Zn
• 分子量: 318.521
• InChiKey: FOKAVZGVFROBPN-DYVFDRNCSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  2-(phenyliminomethyl)pyridine 、 zinc(II) chloride 以 乙醇 为溶剂， 反应 12.0h， 以89.1%的产率得到[(N-phenyl-pyridylmethylideneamino)ZnCl2]
  参考文献：
  名称：

  含N-取代2-亚氨基甲基吡啶和2-亚氨基甲基喹啉的锌(II)预催化剂聚合甲基丙烯酸甲酯和外消旋丙交酯

  摘要：

  摘要 [ZnCl2]与N-环戊基-1-(喹啉-2-基)甲胺(LA)、N-环己基-1-(喹啉-2-基)甲胺(LB)、N-环己基-1-的反应(pyridin-2-yl)methanimine (LC), 2,6-diethyl-N-(pyridin-2-ylmethylene)aniline (LD), N-cyclopentyl-1-(pyridin-2-yl)methanimine (LE),和 N-苯基-(吡啶-2-基)甲胺 (LF) 在乙醇中产生二齿 [(NN')ZnCl2] 络合物、[LAZnCl2]、[LBZnCl2]、[LCZnCl2]、[LDZnCl2]、[LEZnCl2] 和[LFZnCl2]，分别。分子结构表明，[LnZnCl2] (Ln = LA - LD) 中的锌表现出扭曲的四面体几何形状，包括两个 N,N'-二齿配体的氮和两个氯化物配体。大多数这些引发剂对于甲基丙烯酸甲酯

  DOI：

  10.1080/00958972.2017.1416106

文献信息

• Synthesis and characterization of some water soluble Zn(<scp>ii</scp>) complexes with (E)-N-(pyridin-2-ylmethylene)arylamines that regulate tumour cell death by interacting with DNA
  作者：Tushar S. Basu Baul、Sajal Kundu、Anthony Linden、Nune Raviprakash、Sunil K. Manna、M. Fátima C. Guedes da Silva

  DOI：10.1039/c3dt52062e

  日期：——

  The synthesis and spectroscopic properties of nine water soluble zinc(II) complexes of (E)-N-(pyridin-2-ylmethylene)arylamines (Ln) with the general formula [Zn(X)2(Ln)] (X = Cl−, Br−, I−; (1–8)) and [Zn(μ-N3)(N3)(L3)]2 (9) are reported. The complexes were characterized by elemental analysis and their spectroscopic properties were studied using UV-Visible, fluorescence, IR and 1H NMR spectroscopies

  通式[Zn（X）2（L n）]（X ）的（E）-N-（吡啶-2-基亚甲基）芳基胺（L n）的九种水溶性锌（II）配合物的合成和光谱性质=氯- ，溴- ，我- ;（1-8））和[锌（μ-N 3）（N 3）（L 3）] 2（9）中报告。将复合物用元素分析荧光，IR和表征，并使用紫外-可见光进行了研究其光谱性质，11 H NMR光谱。锌（II）配合物2-4和6-9的固态结构是通过单晶X射线晶体学确定的。大部分结构是单核与四坐标锌中心（2-4，6和7，除了其中L携带能够协调锌（额外的供体原子）8），在这种情况下，锌原子具有一个扭曲的四方锥。的中心对称分子[锌（μ-N 3）（N 3）（L 3）] 2（9）在三角双锥体配位环境中与锌原子成双核。一般来说，dichlorozinc衍生物1，3-5和8表现出适度升高的体外细胞毒性朝向人上皮宫颈癌（HeLa细胞）细胞系的效力，以4为最佳表演者（IC 50为18μm的值）。通过3-（4
• Synthesis and structural diversity of 2-pyridylmethylideneamine complexes of zinc(II) chloride
  作者：Martin Schulz、Maurice Klopfleisch、Helmar Görls、Marcel Kahnes、Matthias Westerhausen

  DOI：10.1016/j.ica.2009.06.044

  日期：2009.10

  The addition reactions of zinc(II) chloride to N-substituted pyridine-2-carbaldimines [Py-CH=NR, R = Me (1a), Ph (1b), Bz (1c), allyl (1d)] lead to different complexes dependent on the N-bound substituent R. The 1:1 complexes show molecular structures of the type [(Py-CH=NR) ZnCl2] for R = methyl (2a), phenyl (2b), and allyl (2d) with a distorted tetrahedral environment for the zinc atom. The zinc complex with the N-methylated pyridine-2-carbaldimine also forms a dimer of the type [(Py-CH=NR)ZnCl2](2) (2a)(2) with a square pyramidal coordination sphere of zinc. A 3: 2 stoichiometry is observed for R = benzyl and an ion pair of the type [Zn(Py-CH=NR)(3)](2+) [ZnCl4](2) (2c) is found in the solid state. (C) 2009 Elsevier B. V. All rights reserved.
• Development of Bifunctional Stilbene Derivatives for Targeting and Modulating Metal-Amyloid-β Species
  作者：Joseph J. Braymer、Jung-Suk Choi、Alaina S. DeToma、Chen Wang、Kisoo Nam、Jeffrey W. Kampf、Ayyalusamy Ramamoorthy、Mi Hee Lim

  DOI：10.1021/ic2012205

  日期：2011.11.7

  Amyloid-beta (A beta) peptides and their metal-associated aggregated states have been implicated in the pathogenesis of Alzheimer's disease (AD). Although the etiology of AD remains uncertain, understanding the role of metal-A beta species could provide insights into the onset and development of the disease. To unravel this, bifunctional small molecules that can specifically target and modulate metal-A beta species have been developed, which could serve as suitable chemical tools for investigating metal-A beta-associated events in AD. Through a rational structure-based design principle involving the incorporation of a metal binding site into the structure of an A beta interacting molecule, we devised stilbene derivatives (L1-a and L1-b) and demonstrated their reactivity toward metal-A beta species. In particular, the dual functions of compounds with different structural features (e.g., with or without a dimethylamino group) were explored by UV-vis, X-ray crystallography, high-resolution 2D NMR, and docking studies. Enhanced bifunctionality of compounds provided greater effects on metal-induced A beta aggregation and neurotoxicity in vitro and in living cells. Mechanistic investigations of the reaction of L1-a and L1-b with Zn2+-A beta species by UV-vis and 2D NMR suggest that metal chelation with ligand and/or metal ligand interaction with the A beta peptide may be driving factors for the observed modulation of metal-A beta aggregation pathways. Overall, the studies presented herein demonstrate the importance of a structure-interaction-reactivity relationship for designing small molecules to target metal-A beta species allowing for the modulation of metal-induced A beta reactivity and neurotoxicity.