Cu(norfloxacin)(4'-(3-chlorophenyl)-2,2':6',2''-terpyridine)Cl | 1379455-62-5

• 英文名称: Cu(norfloxacin)(4'-(3-chlorophenyl)-2,2':6',2''-terpyridine)Cl
• CAS: 1379455-62-5
• 化学式: C₃₇H₃₁Cl₂CuFN₆O₃
• 分子量: 761.142
• InChiKey: VBKGZTPIWKVYOA-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  copper(II) choride dihydrate 、 4'-(3-chlorophenyl)-2,2':6',2''-terpyridine 、 诺氟沙星 在 CH₃ONa 、 HCl 作用下， 以 甲醇 为溶剂， 以64.7%的产率得到Cu(norfloxacin)(4'-(3-chlorophenyl)-2,2':6',2''-terpyridine)Cl
  参考文献：
  名称：

  Copper(II) complexes with norfloxacin and neutral terpyridines: Cytotoxic, antibacterial, superoxide dismutase and DNA-interaction approach

  摘要：

  Cu(II) complexes of the type [Cu(NFL)(L-n)Cl] (L-n = substituted terpyridines, NFL = norfloxacin) were synthesised and characterized. Antibacterial activity was assayed against selective Gram((+ve)) and Gram((-ve)) microorganisms using the double dilution technique. The binding behavior of the complexes toward Herring Sperm (HS) DNA was determined using absorption titration and hydrodynamic measurements, whereas the cleavage efficacy of the complexes toward pUC19 DNA was determined by the gel electrophoresis technique. The brine shrimp bioassay was carried out to study the in vitro cytotoxic properties of the synthesized metal complexes. The superoxide dismutase (SOD) like activity of the complexes was measured using an NBT/NADH/PMS system and is expressed in term of the concentration of complex which terminates the formation of formazan by 50% (IC50 value). The IC50 values were observed to be in the range 0.653-1.344 mu M. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.03.050