p-nitro-Pifithrin-alpha parent | 760937-54-0

• 英文名称: p-nitro-Pifithrin-alpha parent
• 英文别名: 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-nitrophenyl)ethanone
• CAS: 760937-54-0
• 化学式: C15H15N3O3S
• 分子量: 317.4
• InChiKey: NTTZNTVGYWOCJT-UHFFFAOYSA-N

物化性质

• 沸点：
  506.6±56.0 °C(Predicted)
• 密度：
  1.48±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Tetrahydrobenzothiazole analogues as neuroprotective agents
  申请人：——

  公开号：US20040067991A1

  公开（公告）日：2004-04-08

  This invention relates generally to tetrahydrobenzothiazole analogues and tetrahydrobenzooxyzole analogues, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to methods of treatment using these compounds. The invention also encompasses pharmaceutically acceptable esters, amides, and salts of such compounds. The invention further provides a method of reducing or delaying apoptosis in a population of cells, comprising contacting the population of cells with a tetrahydrobenzothiazole analogue or a tetrahydrobenzooxyzole analogue, thereby reducing or delaying apoptosis in the population of cells.

  本发明涉及四氢苯并噻唑类似物和四氢苯并噁唑类似物，包括这些化合物和药物可接受载体的制药组合物，以及使用这些化合物的治疗方法。本发明还包括这些化合物的药物可接受酯，酰胺和盐。本发明还提供一种减少或延迟细胞群中凋亡的方法，包括将四氢苯并噻唑类似物或四氢苯并噁唑类似物与细胞群接触，从而减少或延迟细胞群中的凋亡。
• TETRAHYDROBENZOTHIAZOLE ANALOGUES AS NEUROPROTECTIVE AGENTS
  申请人：Greig Nigel H

  公开号：US20080319032A1

  公开（公告）日：2008-12-25

  This invention relates generally to tetrahydrobenzothiazole analogues and tetrahydrobenzooxyzole analogues, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to methods of treatment using these compounds. The invention also encompasses pharmaceutically acceptable esters, amides, and salts of such compounds. The invention further provides a method of reducing or delaying apoptosis in a population of cells, comprising contacting the population of cells with a tetrahydrobenzothiazole analogue or a tetrahydrobenzooxyzole analogue, thereby reducing or delaying apoptosis in the population of cells.

  本发明涉及四氢苯并噻唑类似物和四氢苯并噁唑类似物，以及包括这些化合物和药用可接受载体的制药组合物和使用这些化合物的治疗方法。本发明还包括这些化合物的药用可接受酯、酰胺和盐。本发明还提供一种减少或延迟细胞群体凋亡的方法，包括将细胞群体与四氢苯并噻唑类似物或四氢苯并噁唑类似物接触，从而减少或延迟细胞群体的凋亡。
• METHOD OF EFFICIENTLY ESTABLISHING INDUCED PLURIPOTENT STEM CELLS
  申请人：Kyoto University

  公开号：EP2288692B1

  公开（公告）日：2017-08-02
• METHOD FOR PRODUCING MAST CELLS FROM PLURIPOTENT STEM CELLS
  申请人：Kyoto University

  公开号：EP2475767A1

  公开（公告）日：2012-07-18
• METHODS AND COMPOSITIONS FOR ENHANCING GENE EDITING
  申请人：Novartis AG

  公开号：EP3535396A1

  公开（公告）日：2019-09-11