| 183016-27-5

• CAS: 183016-27-5
• 化学式: C₉H₂₀Cl₂N₃OPt
• 分子量: 452.263
• InChiKey: ASZFXDKKAVYWTD-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  potassium tetrachloroplatinate(II) 、 3,4-Diamino-2,2,6,6-tetramethylpiperidine-1-oxyl 以 水 为溶剂， 以78%的产率得到
  参考文献：
  名称：

  Synthesis of dinitroxylcis-diaminoplatinum(ii) complexes and their interaction with DNA

  摘要：

  Dinitroxyl complexes of platinum, cis-Pt-II(APO)(2)X-2, where APO is 4-amino-2,2,6,6-tetramethylpiperidine- 1-oxyl, were obtained by either a direct reaction of APO with K2PtX4 (X = Cl or I) or a replacement of iodide ligands in cis-Pt-II(APO)(2)I-2 by nitrate and oxalate ligands. The interaction of water-soluble cis-Pt-II(APO)(2)(NO3)(2) with ox spleen DNA resulted in platinated DNA with a degree of modification (r) similar to 7 times lower than that obtained with cis-Pt-II(NH3)(2)Cl-2 (cisplatin). Melting point T-m, melting range Delta T, and the degree of hyperchromicity Delta H for platinated DNA showed that for equal r values, the cis-Pt-II(APO)(2)-DNA adducts increase heterogeneity in the DNA structure much more effectively than the cis-Pt-II(NH3)(2)-DNA adducts. Poor platinating activity, substantial disturbance of the DNA structure, as well as low toxicity and moderate antitumor activity of cis-Pt-II(APO)(2)X-2 complexes are probably explained by steric hindrances caused by two bulky APO ligands.

  DOI：

  10.1007/bf02495618