tetramethylammonium [RuCl3(2-methyl-8-quinolinato)(nitrosyl)] | 135515-76-3

• 英文名称: tetramethylammonium [RuCl3(2-methyl-8-quinolinato)(nitrosyl)]
• 英文别名: [(CH₃)₄N][RuCl₃(2mqn)(NO)]；(tetramethylammonium)[RuCl3(2-methyl-8-quinolinolate)(nitrosyl)]；[(CH3)4N][RuCl3(2-methyl-8-quinolinolato)(NO)]；[NMe4][RuCl3(2-methyl-8-quinolinol)NO]；[(CH3)4N][RuCl3(2mqn)(NO)]
• CAS: 135515-76-3
• 化学式: C₄H₁₂N*C₁₀H₈Cl₃N₂O₂Ru
• 分子量: 469.761
• InChiKey: MTULKYRYMGKLBS-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  tetramethylammonium [RuCl3(2-methyl-8-quinolinato)(nitrosyl)] 、 5-氯-8-羟基喹啉 以 not given 为溶剂， 生成 cis-1 [RuCl(2-methyl-8-quinolinol)(5-chloro-8-quinolinol)NO]
  参考文献：
  名称：

  Substituent effect of 8-quinolinolato ligands on photo-induced isomerization for linear nitrosylruthenium(II) complexes – Experimental study

  摘要：

  cis-1 [RuCl(QN)(QN')NO] (HQN or HQN' = 8-quinolinol, 5-chloro-, 5,7-dichloro-, 2-isopropyl-, 2-ethyl-, 2,4-dimethyl- or 2-methyl-8-quinolinol) complexes and the corresponding trans complexes were prepared. The cis-1 to trans and the trans to cis-1 photo-induced isomerizations were carried out to investigate the substituent effect of the 8-quinolinolato ligands on the isomerization and to elucidate the mechanism. The molar ratio of trans to cis-1 isomer for the isomerization was compared among [RuCl(QN)(QN')NO], [RuCl(QN')(2)NO] and [RuCl(QN)(2)NO]. The results clearly indicate that the chloro, group and bulkiness of the alkyl group in the 8-quinolinolato ligands influence on the isomerization. (c) 2005 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2005.09.066
• 作为产物：
  描述：

  8-羟基喹哪啶 、 ruthenium nitrosyl chloride hydrate 以 not given 为溶剂， 生成 tetramethylammonium [RuCl3(2-methyl-8-quinolinato)(nitrosyl)]
  参考文献：
  名称：

  Substituent effect of 8-quinolinolato ligands on photo-induced isomerization for linear nitrosylruthenium(II) complexes – Experimental study

  摘要：

  cis-1 [RuCl(QN)(QN')NO] (HQN or HQN' = 8-quinolinol, 5-chloro-, 5,7-dichloro-, 2-isopropyl-, 2-ethyl-, 2,4-dimethyl- or 2-methyl-8-quinolinol) complexes and the corresponding trans complexes were prepared. The cis-1 to trans and the trans to cis-1 photo-induced isomerizations were carried out to investigate the substituent effect of the 8-quinolinolato ligands on the isomerization and to elucidate the mechanism. The molar ratio of trans to cis-1 isomer for the isomerization was compared among [RuCl(QN)(QN')NO], [RuCl(QN')(2)NO] and [RuCl(QN)(2)NO]. The results clearly indicate that the chloro, group and bulkiness of the alkyl group in the 8-quinolinolato ligands influence on the isomerization. (c) 2005 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2005.09.066

文献信息

• Photo-induced cytotoxicity, photo-controlled nitric oxide release and DNA/human serum albumin binding of three water-soluble nitrosylruthenium complexes
  作者：Liqun Xu、Zhiou Ma、Wenming Wang、Leilei Xie、Lifang Liu、Jiao Liu、Xuan Zhao、Hongfei Wang

  DOI：10.1016/j.poly.2017.08.036

  日期：2017.11

  radicals. Moreover, the binding constants of the complexes with calf thymus DNA and human serum albumin were calculated by fluorescence spectroscopy to understand the effects of the substituent groups on the biological activity. The [RuCl3(2cqn)(NO)]− complex had the highest binding constant, consistent with its high cytotoxicity. Thus, we developed an effective and simple method to control cytotoxic activities

  摘要钌（Ru）配合物由于其良好的光化学和光生物学特性，已潜在地用作DNA结构探针，细胞显像剂和抗癌药物，因此已被广泛研究。在这里，我们使用8-羟基喹啉（Hhqn）及其衍生物（2-甲基-8-喹啉[H2mqn]和2-配体为cholo-8-quiolinoline [H2cqn]）（QN = hqn，2mqn或2cqn）；通过X射线晶体衍射确认了它们的结构。[RuCl3（2cqn）（NO）]-络合物显示出比其他两种络合物更高的活性，在光下的IC50值为21.5 µM，在没有光照射的情况下的IC50值为100 µM。复合物诱导的抗增殖作用使细胞周期停滞在G2 / M期。此外，通过自旋捕获NO自由基确认了复合物中的光控实时NO释放。还证明了复合物的光化学DNA裂解，这可能是由于光诱导的自由基引起的。此外，通过荧光光谱法计算了与小牛胸腺DNA和人血清白蛋白的复合物的结合常数，以了解取代基对生物活性的影
• Relationship between pKa of 8-quinolinol derivatives and a π-donor ability of the 8-quinolinolato oxygen in linear nitrosylruthenium(II) complexes
  作者：Tsuyoshi Suganuma、Atsushi Tanada、Hiroshi Tomizawa、Mikio Tanaka、Eiichi Miki

  DOI：10.1016/s0020-1693(01)00488-1

  日期：2001.8

  The relationship between the pK(a) of 8-quinolinol derivatives 8-quinolinol (Hqn), 2-methyl- (H2-Meqn), 2,4-dimethyl-(H2,4-diMeqn), 5-chloro- (H5-Clqn) and 5,7-dichloro-8-quinolinols (H5,7-diClqn)} and a pi -donor ability of the 8-quinolinolato oxygens has been investigated by the identification of the structures of the major products, [RuCl(QN)(QN ' )NO] (HQN = 8-quinolinol derivative; HQN ' = different 8-quinolinol derivatives). obtained by the reaction of [RuCl3(QN or QN ' )NO](-) with HQN ' or HQN. The results obtained clearly showed that the oxygen of the 8-quinolinol derivative that has a higher pK(a) predominantly coordinates in the trans position to the NO ligand and is a better pi -electron donor. The order of the pi -electron donor ability for the oxygen of the 8-quinolinol derivatives is as follows: H2-Meqn greater than or equal to H2,4-diMeqn > Hqn greater than or equal to H5-Clqn > H5,7-diClqn, almost agreeing with the magnitude of the pK(a) values of the corresponding 8-quinolinols. The structures of cis-1 [RuCl(5,7-diClqn)(2)NO] and cis-1 [RuCl(5,7-diClqn)(2-Meqn)NO] were determined by X-ray diffraction. (C) 2001 Elsevier Science B.V. All rights reserved.
• Interaction between the NO+ ligand and trans π-donor ligands in chloro(2-methyl-8-quinolinolato) nitrosyl(8-quinolinolato)-ruthenium(II) complexes
  作者：Shoko Nagata-Tanba、Hiroshi Tomizawa、Eiichi Miki、Mikio Tanaka、Takashi Nagai

  DOI：10.1016/s0020-1693(97)05563-1

  日期：1998.1

  The reaction of [RuCl3(2mqn)NO](-) (2mqn is 2-methyl-8-quinolinolato ligand whose phenolate oxygen is trans to the NO) with an excess of 8-quinolinol (Hqn) and the reaction of [RuCl3(qn)NO](-) (phenolate oxygen in the qn is trans to the NO) with an excess of 2-methyl-8-quinolinol give [RuCl(2mqn)(qn)NO] (1) as a major product, in which oxygen of the 2mqn is trans to the NO and the configuration of the ligating nitrogen atoms of the qn and 2mqn is trans(N,N). The methyl group in the 2-position of qn causes the oxygen in the 2mqn to coordinate predominantly in the trans position to the NO+ ligand. (C) 1998 Elsevier Science S.A.
• The unexpected reactions of [RuCl3(2mqn)NO]− (H2mqn=2-methyl-8-quinolinol) with 2-chloro-8-quinolinol (H2cqn) and of [RuCl(2cqn)(2mqn)NO] on photoirradiation
  作者：Hongfei Wang、Takashi Onozuka、Hiroshi Tomizawa、Mikio Tanaka、Eiichi Miki

  DOI：10.1016/j.ica.2003.09.031

  日期：2004.3

  The reaction of [RuCl3(2mqn)NO](-) (H2mqn=2-methyl-8-quinolinol) with 2-chloro-8-quinolinol (H2cqn) afforded cis-1 [RuCl(2cqn)(2mqn)NO] (the oxygen of 2cqn is trans to the NO) (complex 1), cis-1 [RuCl(2cqn)(2mqn)NO] (the oxygen of 2mqn is trans to the NO) (complex 2) and a 1:1 mixture of cis-2 [RuCl(2cqn)(2mqn)NO] (the oxygen of 2mqn is trans to the NO) and cis-2 [RuCl(2cqn)(2mqn)NO] (the oxygen of 2cqn is trans to the NO) (complex 3). The reaction was compared with that of [RuCl3(2mqn)NO]- with 8-quinolinol (Hqn) or 5-chloro-8-quinolinol (H5cqn). Photoirradiation reaction of complex 1 at room temperature in deaerated CH2Cl2 in the presence of NO gave trans-[RuCl(2cqn)(2mqn)NO] (the Cl is trans to the NO) and complex 2 with recovery of complex 1. The reaction was contrasted with that of cis-1 [RuCl(qn)(2mqn)NO] or cis-1 [RuCl(5cqn)(2mqn)NO]. The crystal structure of complex 1 was determined by X-ray diffraction. The reactions were examined under consideration of atomic charge of the phenolato oxygen in 8-quinolinol and its derivatives calculated at the restricted Hartree-Fock/6-3116** level. (C) 2003 Elsevier B.V. All rights reserved.