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    首页 分子通 按分子结构分类 有机化合物 有机杂环化合物 二嗪烷类

    二嗪烷类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 6-[4-(4-Fluorophenyl)piperazin-1-yl]-1,4-dimethyl-2-oxo-5-[(4-oxo-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]pyridine-3-carbonitrile —— C25H24FN5O2S2
    6-[4-(4-Fluorophenyl)piperazin-1-yl]-1,4-dimethyl-2-oxo-5-[(4-oxo-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]pyridine-3-carbonitrile
    —— 5-[(3-Dodecyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-dimethyl-2-oxo-6-(4-phenylpiperazin-1-yl)pyridine-3-carbonitrile —— C34H45N5O2S2
    5-[(3-Dodecyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-dimethyl-2-oxo-6-(4-phenylpiperazin-1-yl)pyridine-3-carbonitrile
    —— 1,4-Dimethyl-2-oxo-5-[[4-oxo-3-(1-phenylethyl)-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-6-(4-phenylpiperazin-1-yl)pyridine-3-carbonitrile —— C30H29N5O2S2
    1,4-Dimethyl-2-oxo-5-[[4-oxo-3-(1-phenylethyl)-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-6-(4-phenylpiperazin-1-yl)pyridine-3-carbonitrile
    —— 3-[5-[[5-Cyano-2-[4-(2-fluorophenyl)piperazin-1-yl]-1,4-dimethyl-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid —— C25H24FN5O4S2
    3-[5-[[5-Cyano-2-[4-(2-fluorophenyl)piperazin-1-yl]-1,4-dimethyl-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid
    —— 6-(4-Benzylpiperazin-1-yl)-5-[[3-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-2-oxopyridine-3-carbonitrile —— C34H33N7O3S2
    6-(4-Benzylpiperazin-1-yl)-5-[[3-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-2-oxopyridine-3-carbonitrile
    —— 5-[[3-(1,1-Dioxothiolan-3-yl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-2-oxo-6-(4-phenylpiperazin-1-yl)pyridine-3-carbonitrile —— C26H27N5O4S3
    5-[[3-(1,1-Dioxothiolan-3-yl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-2-oxo-6-(4-phenylpiperazin-1-yl)pyridine-3-carbonitrile
    —— 6-(4-Benzylpiperazin-1-yl)-5-[[3-[2-(3,4-dimethoxyphenyl)ethyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-2-oxopyridine-3-carbonitrile —— C33H35N5O4S2
    6-(4-Benzylpiperazin-1-yl)-5-[[3-[2-(3,4-dimethoxyphenyl)ethyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-2-oxopyridine-3-carbonitrile
    —— 5-[[3-[2-(3,4-Dimethoxyphenyl)ethyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-6-(4-ethylpiperazin-1-yl)-1,4-dimethyl-2-oxopyridine-3-carbonitrile —— C28H33N5O4S2
    5-[[3-[2-(3,4-Dimethoxyphenyl)ethyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-6-(4-ethylpiperazin-1-yl)-1,4-dimethyl-2-oxopyridine-3-carbonitrile
    —— 5-[(3-Dodecyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-dimethyl-6-(4-methylpiperazin-1-yl)-2-oxopyridine-3-carbonitrile —— C29H43N5O2S2
    5-[(3-Dodecyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-dimethyl-6-(4-methylpiperazin-1-yl)-2-oxopyridine-3-carbonitrile
    —— 5-[[3-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-6-(4-ethylpiperazin-1-yl)-1,4-dimethyl-2-oxopyridine-3-carbonitrile —— C29H31N7O3S2
    5-[[3-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-6-(4-ethylpiperazin-1-yl)-1,4-dimethyl-2-oxopyridine-3-carbonitrile
    —— 6-(4-Ethylpiperazin-1-yl)-1,4-dimethyl-5-[[3-[(4-methylphenyl)methyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-2-oxopyridine-3-carbonitrile —— C26H29N5O2S2
    6-(4-Ethylpiperazin-1-yl)-1,4-dimethyl-5-[[3-[(4-methylphenyl)methyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-2-oxopyridine-3-carbonitrile
    —— 5-[(3-Heptyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-dimethyl-6-(4-methylpiperazin-1-yl)-2-oxopyridine-3-carbonitrile —— C24H33N5O2S2
    5-[(3-Heptyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-dimethyl-6-(4-methylpiperazin-1-yl)-2-oxopyridine-3-carbonitrile
    —— 11-[5-[[5-Cyano-1,4-dimethyl-2-(4-methylpiperazin-1-yl)-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]undecanoic acid —— C28H39N5O4S2
    11-[5-[[5-Cyano-1,4-dimethyl-2-(4-methylpiperazin-1-yl)-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]undecanoic acid
    —— 3-[5-[[5-Cyano-2-(4-ethylpiperazin-1-yl)-1,4-dimethyl-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid —— C21H25N5O4S2
    3-[5-[[5-Cyano-2-(4-ethylpiperazin-1-yl)-1,4-dimethyl-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid
    —— 11-[5-[[5-Cyano-2-(4-ethylpiperazin-1-yl)-1,4-dimethyl-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]undecanoic acid —— C29H41N5O4S2
    11-[5-[[5-Cyano-2-(4-ethylpiperazin-1-yl)-1,4-dimethyl-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]undecanoic acid
    —— 6-[4-(2-Fluorophenyl)piperazin-1-yl]-5-[[3-[(4-methoxyphenyl)methyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-2-oxopyridine-3-carbonitrile —— C30H28FN5O3S2
    6-[4-(2-Fluorophenyl)piperazin-1-yl]-5-[[3-[(4-methoxyphenyl)methyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-2-oxopyridine-3-carbonitrile
    —— 5-[[3-[(4-Methoxyphenyl)methyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-2-oxo-6-(4-phenylpiperazin-1-yl)pyridine-3-carbonitrile —— C30H29N5O3S2
    5-[[3-[(4-Methoxyphenyl)methyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-2-oxo-6-(4-phenylpiperazin-1-yl)pyridine-3-carbonitrile
    —— 11-[5-[[2-(4-Benzylpiperazin-1-yl)-5-cyano-1,4-dimethyl-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]undecanoic acid —— C34H43N5O4S2
    11-[5-[[2-(4-Benzylpiperazin-1-yl)-5-cyano-1,4-dimethyl-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]undecanoic acid
    —— 2-[5-[[5-Cyano-1,4-dimethyl-2-(4-methylpiperazin-1-yl)-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid —— C19H21N5O4S2
    2-[5-[[5-Cyano-1,4-dimethyl-2-(4-methylpiperazin-1-yl)-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid
    —— 6-(4-Ethylpiperazin-1-yl)-5-[(3-heptyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-dimethyl-2-oxopyridine-3-carbonitrile —— C25H35N5O2S2
    6-(4-Ethylpiperazin-1-yl)-5-[(3-heptyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-dimethyl-2-oxopyridine-3-carbonitrile
    —— 6-(4-Benzylpiperazin-1-yl)-1,4-dimethyl-2-oxo-5-[[4-oxo-3-(1-phenylethyl)-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]pyridine-3-carbonitrile —— C31H31N5O2S2
    6-(4-Benzylpiperazin-1-yl)-1,4-dimethyl-2-oxo-5-[[4-oxo-3-(1-phenylethyl)-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]pyridine-3-carbonitrile
    —— 6-(4-Benzylpiperazin-1-yl)-5-[[3-(2-ethylhexyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-2-oxopyridine-3-carbonitrile —— C31H39N5O2S2
    6-(4-Benzylpiperazin-1-yl)-5-[[3-(2-ethylhexyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-2-oxopyridine-3-carbonitrile
    —— 5-[[3-(2-Ethylhexyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-6-(4-methylpiperazin-1-yl)-2-oxopyridine-3-carbonitrile —— C25H35N5O2S2
    5-[[3-(2-Ethylhexyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-6-(4-methylpiperazin-1-yl)-2-oxopyridine-3-carbonitrile
    —— 6-[5-[[5-Cyano-2-(4-ethylpiperazin-1-yl)-1,4-dimethyl-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]hexanoic acid —— C24H31N5O4S2
    6-[5-[[5-Cyano-2-(4-ethylpiperazin-1-yl)-1,4-dimethyl-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]hexanoic acid
    —— 4-[5-[[5-Cyano-1,4-dimethyl-2-(4-methylpiperazin-1-yl)-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid —— C21H25N5O4S2
    4-[5-[[5-Cyano-1,4-dimethyl-2-(4-methylpiperazin-1-yl)-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid
    —— 6-(4-Benzylpiperazin-1-yl)-5-[(3-heptyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-dimethyl-2-oxopyridine-3-carbonitrile —— C30H37N5O2S2
    6-(4-Benzylpiperazin-1-yl)-5-[(3-heptyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-dimethyl-2-oxopyridine-3-carbonitrile
    —— 6-[5-[[2-(4-Benzylpiperazin-1-yl)-5-cyano-1,4-dimethyl-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]hexanoic acid —— C29H33N5O4S2
    6-[5-[[2-(4-Benzylpiperazin-1-yl)-5-cyano-1,4-dimethyl-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]hexanoic acid
    —— 6-[5-[[5-Cyano-1,4-dimethyl-2-(4-methylpiperazin-1-yl)-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]hexanoic acid —— C23H29N5O4S2
    6-[5-[[5-Cyano-1,4-dimethyl-2-(4-methylpiperazin-1-yl)-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]hexanoic acid
    —— 3-[5-[[5-Cyano-1,4-dimethyl-2-(4-methylpiperazin-1-yl)-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid —— C20H23N5O4S2
    3-[5-[[5-Cyano-1,4-dimethyl-2-(4-methylpiperazin-1-yl)-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid
    —— 5-[[3-(1,1-Dioxothiolan-3-yl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-6-(4-methylpiperazin-1-yl)-2-oxopyridine-3-carbonitrile —— C21H25N5O4S3
    5-[[3-(1,1-Dioxothiolan-3-yl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-6-(4-methylpiperazin-1-yl)-2-oxopyridine-3-carbonitrile
    —— 1,4-Dimethyl-6-(4-methylpiperazin-1-yl)-5-[(3-octyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-2-oxopyridine-3-carbonitrile —— C25H35N5O2S2
    1,4-Dimethyl-6-(4-methylpiperazin-1-yl)-5-[(3-octyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-2-oxopyridine-3-carbonitrile
    —— 5-[[3-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-6-(4-methylpiperazin-1-yl)-2-oxopyridine-3-carbonitrile —— C28H29N7O3S2
    5-[[3-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-6-(4-methylpiperazin-1-yl)-2-oxopyridine-3-carbonitrile
    —— 2-[5-[[5-Cyano-2-(4-ethylpiperazin-1-yl)-1,4-dimethyl-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid —— C20H23N5O4S2
    2-[5-[[5-Cyano-2-(4-ethylpiperazin-1-yl)-1,4-dimethyl-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid
    —— 5-[[3-[2-(3,4-Dimethoxyphenyl)ethyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-6-(4-methylpiperazin-1-yl)-2-oxopyridine-3-carbonitrile —— C27H31N5O4S2
    5-[[3-[2-(3,4-Dimethoxyphenyl)ethyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-1,4-dimethyl-6-(4-methylpiperazin-1-yl)-2-oxopyridine-3-carbonitrile
    —— 5-[[3-(1,1-Dioxothiolan-3-yl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-6-(4-ethylpiperazin-1-yl)-1,4-dimethyl-2-oxopyridine-3-carbonitrile —— C22H27N5O4S3
    5-[[3-(1,1-Dioxothiolan-3-yl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-6-(4-ethylpiperazin-1-yl)-1,4-dimethyl-2-oxopyridine-3-carbonitrile
    —— 6-[4-[4-(3-chlorophenyl)oxane-4-carbonyl]piperazin-1-yl]pyridine-3-carbonitrile —— C22H23ClN4O2
    6-[4-[4-(3-chlorophenyl)oxane-4-carbonyl]piperazin-1-yl]pyridine-3-carbonitrile
    —— (2,5-dimethylfuran-3-yl)-[4-[(3S)-3-methylpiperidin-1-yl]sulfonylpiperazin-1-yl]methanone —— C17H27N3O4S
    (2,5-dimethylfuran-3-yl)-[4-[(3S)-3-methylpiperidin-1-yl]sulfonylpiperazin-1-yl]methanone
    —— 1-[(2R)-2-[4-(4-chloro-2-nitrophenyl)piperazine-1-carbonyl]pyrrolidin-1-yl]butan-1-one —— C19H25ClN4O4
    1-[(2R)-2-[4-(4-chloro-2-nitrophenyl)piperazine-1-carbonyl]pyrrolidin-1-yl]butan-1-one
    —— (2S)-1-[4-(4-chloro-2-nitrophenyl)piperazin-1-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propan-1-one —— C16H19ClN6O3S
    (2S)-1-[4-(4-chloro-2-nitrophenyl)piperazin-1-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propan-1-one
    —— 1-methyl-N-[(2R)-4-[4-(3-methylphenyl)piperazin-1-yl]butan-2-yl]pyrazole-4-sulfonamide —— C19H29N5O2S
    1-methyl-N-[(2R)-4-[4-(3-methylphenyl)piperazin-1-yl]butan-2-yl]pyrazole-4-sulfonamide
    —— (2S)-1-[4-(3,3-dimethylbutyl)piperazin-1-yl]-2-methylbutan-1-one —— C15H30N2O
    (2S)-1-[4-(3,3-dimethylbutyl)piperazin-1-yl]-2-methylbutan-1-one
    —— [4-(3,3-dimethylbutyl)piperazin-1-yl]-[(1R,2R)-2-methylcyclopropyl]methanone —— C15H28N2O
    [4-(3,3-dimethylbutyl)piperazin-1-yl]-[(1R,2R)-2-methylcyclopropyl]methanone
    —— (2R)-1-[4-(3,3-dimethylbutyl)piperazin-1-yl]-2-methylbutan-1-one —— C15H30N2O
    (2R)-1-[4-(3,3-dimethylbutyl)piperazin-1-yl]-2-methylbutan-1-one
    —— [4-(3,3-dimethylbutyl)piperazin-1-yl]-[(1S,2R)-2-methylcyclopropyl]methanone —— C15H28N2O
    [4-(3,3-dimethylbutyl)piperazin-1-yl]-[(1S,2R)-2-methylcyclopropyl]methanone
    —— (Z)-2-(4-methylphenyl)-N-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propyl]ethenesulfonamide —— C20H27N5O2S
    (Z)-2-(4-methylphenyl)-N-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propyl]ethenesulfonamide
    —— (E)-2-(4-methylphenyl)-N-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propyl]ethenesulfonamide —— C20H27N5O2S
    (E)-2-(4-methylphenyl)-N-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propyl]ethenesulfonamide
    —— 2-methyl-4-(4-methylpiperazin-1-yl)-6-prop-2-enyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine —— C16H25N5
    2-methyl-4-(4-methylpiperazin-1-yl)-6-prop-2-enyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine
    —— N-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]-3-(2-oxo-1,3-oxazolidin-3-yl)propanamide —— C18H23F3N4O3
    N-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]-3-(2-oxo-1,3-oxazolidin-3-yl)propanamide
    —— N-[2-(4-ethylpiperazin-1-yl)phenyl]-2-propylsulfonylacetamide —— C17H27N3O3S
    N-[2-(4-ethylpiperazin-1-yl)phenyl]-2-propylsulfonylacetamide
    —— 4-(4-methylpiperazin-1-yl)-2-phenyl-6-prop-2-enyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine —— C21H27N5
    4-(4-methylpiperazin-1-yl)-2-phenyl-6-prop-2-enyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine