(R)-4-(2-氟-4-(5-(羟基甲基)-2-氧代噁唑啉-3-基)苯基)哌嗪-1-羧酸叔丁酯 | 154590-62-2
中文名称
(R)-4-(2-氟-4-(5-(羟基甲基)-2-氧代噁唑啉-3-基)苯基)哌嗪-1-羧酸叔丁酯
中文别名
——
英文名称
(R)-tert-butyl 4-(2-fluoro-4-(5-(hydroxymethyl)-2-oxooxazolidin-3-yl)phenyl)piperazine-1-carboxylate
英文别名
tert-butyl 4-(4-{(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl)piperazine-1-carboxylate；5(R)-hydroxymethyl-3-(3-fluoro-4-(4-t-butoxycarbonylpiperazin-1-yl)phenyl)oxazolidin-2-one；(5R)-[3-[3-fluoro-4-[N-t-butoxycarbonylpiperazin-1-yl]phenyl]-2-oxo-5-oxazolidinylmethyl] alcohol；(5S)-[3-[3-fluoro-4-[N-t-butoxycarbonylpiperazin-1-yl]phenyl]-2-oxooxazolidin-5-ylmethyl]alcohol；tert-butyl 4-{2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}piperazine-1-carboxylate；(S)-[3-[3-fluoro-4-[N-t-butoxycarbonylpiperazin-1-yl]phenyl]-2-oxooxazolidin-5-yl] methanol；tert-butyl 4-[2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperazine-1-carboxylate
CAS
154590-62-2
化学式
C19H26FN3O5
mdl
——
分子量
395.431
InChiKey
MOYRUYYEQYIFJI-CQSZACIVSA-N
BEILSTEIN
——
EINECS
——
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物化性质
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计算性质
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ADMET
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安全信息
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SDS
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制备方法与用途
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上下游信息
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文献信息
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表征谱图
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同类化合物
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相关功能分类
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相关结构分类
物化性质
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熔点：130-131 °C
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沸点：552.2±50.0 °C(Predicted)
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密度：1.297±0.06 g/cm3(Predicted)
计算性质
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辛醇/水分配系数(LogP)：1.7
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重原子数：28
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可旋转键数：5
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环数：3.0
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sp3杂化的碳原子比例：0.58
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拓扑面积：82.6
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氢给体数：1
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氢受体数：7
SDS
上下游信息
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上游原料
中文名称 英文名称 CAS号 化学式 分子量 —— tert-butyl 4-(4-(((benzyloxy)carbonyl)amino)-2-fluorophenyl)-piperazine-1-carboxylate 154590-36-0 C23H28FN3O4 429.491 4-(4-Boc-哌嗪-1-基)-3-氟苯胺 tert-butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate 154590-35-9 C15H22FN3O2 295.357 4-(2-氟-4-硝基苯基)哌嗪-1-羧酸叔丁酯 4-(2-fluoro-4-nitrophenyl)-piperazine-1-carboxylic acid tert butyl ester 154590-34-8 C15H20FN3O4 325.34 -
下游产品
中文名称 英文名称 CAS号 化学式 分子量 —— [N-3-(1-tert-butoxycarbonyl)-4-(2-fluoro-4-piperazinyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate 154590-63-3 C20H28FN3O7S 473.523 (S)-叔丁基-4-(4-(5-(氨甲基)-2-羰基恶唑烷酮-3-基)-2-氟苯基)哌嗪-1-羧酸 tert-butyl (S)-4-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazine-1-carboxylate 268209-15-0 C19H27FN4O4 394.446 —— (R)-N-[[3-[3-fluoro-4-(N-piperazinyl)]-phenyl]-2-oxo-5-oxazolidinyl]methylalcohol 216869-31-7 C14H18FN3O3 295.314 —— tert-butyl 4-(4-{(5R)-5-[(ethylthio)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl)piperazine-1-carboxylate 885013-05-8 C21H30FN3O4S 439.551 —— (R)-tert-butyl 4-(4-(5-(azidomethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazine-1-carboxylate 154590-64-4 C19H25FN6O4 420.444 —— tert-butyl (S)-4-[4-[5-(acetamidomethyl)-2-oxooxazolidin-3-yl]-2-fluorophenyl]piperazine-1-carboxylate 154590-65-5 C21H29FN4O5 436.483 —— tert-butyl 4-(2-fluoro-4-{(5R)-2-oxo-5-[(pyrazin-2-yloxy)methyl]-1,3-oxazolidin-3-yl}phenyl)piperazine-1-carboxylate 885013-10-5 C23H28FN5O5 473.504 —— tert-butyl 4-(2-fluoro-4-{(5R)-5-[(heptylthio)methyl]-2-oxo-1,3-oxazolidin-3-yl}phenyl)piperazine-1-carboxylate 885013-06-9 C26H40FN3O4S 509.686 —— tert-butyl 4-(2-fluoro-4-{(5R)-5-[(isoxazol-3-yloxy)methyl]-2-oxo-1,3-oxazolidin-3-yl}phenyl)piperazine-1-carboxylate 252279-83-7 C22H27FN4O6 462.478 —— [(5R)-3-(3-fluoro-4-piperazin-1-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl acetate —— C16H20FN3O4 337.351 —— (R)-(3-(4-(4-acetylpiperazin-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate 1123888-62-9 C17H22FN3O6S 415.443 —— tert-butyl 4-(2-fluoro-4-{(5R)-5-[(2-naphthylthio)methyl]-2-oxo-1,3-oxazolidin-3-yl}phenyl)piperazine-1-carboxylate 885013-07-0 C29H32FN3O4S 537.655 —— (5R)-3-(3-fluoro-4-piperazin-1-ylphenyl)-5-[(isoxazol-3-yloxy)methyl]-1,3-oxazolidin-2-one 252279-84-8 C17H19FN4O4 362.361 —— (S)-N-[[3-[3-fluoro-4-[4-(cyanomethyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]thioacetamide 887275-12-9 C18H22FN5O2S 391.469 (S)-N-((3-(3-氟-4-(哌嗪-1-基)苯基)-2-氧代噁唑啉-5-基)甲基)乙酰胺 (S)-N-[[3-[3-fluoro-4-(1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 154590-66-6 C16H21FN4O3 336.366 —— (S)-N-[[3-[3-fluoro-4-[4-(cyanomethyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]-methyl]-O-methylthiocarbamate 887275-15-2 C18H22FN5O3S 407.469 —— 5(R)-hydroxymethyl-3-(4-(4-(5-cyanopyrid-2-yl)piperazin-1-yl)-3-fluorophenyl)-oxazolidin-2-one 252328-85-1 C20H20FN5O3 397.409 —— tert-butyl 4-{4-[(5S)-5-({[(5-chloro-2-thienyl)carbonyl]amino}methyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenyl}piperazine-1-carboxylate 348626-16-4 C24H28ClFN4O5S 539.028 —— (5R)-3-{3-fluoro-4-[4-(5-nitro-2-thienyl)piperazin-1-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazolidin-2-one 885012-90-8 C18H19FN4O5S 422.437 —— ((5R)-3-{3-fluoro-4-[4-(5-nitro-2-thienyl)piperazin-1-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl acetate 885012-89-5 C20H21FN4O6S 464.474 —— ((5R)-3-{3-fluoro-4-[4-(5-nitro-2-thienyl)piperazin-1-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl-n-butylcarbamate —— C23H28FN5O6S 521.57 —— O-[((5R)-3-{3-fluoro-4-[4-(5-nitro-2-thienyl)piperazin-1-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl] isopropylthiocarbamate —— C22H26FN5O5S2 523.609 —— 5(R)-pyrid-2-yloxymethyl-3-(4-(4-(5-cyanopyrid-2-yl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one —— C25H23FN6O3 474.494 —— N-((S)-3-{3-Fluoro-4-[4-(5-hydroxymethyl-furan-2-ylmethyl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide 548762-76-1 C22H27FN4O5 446.479 —— 5(R)-pyrimidin-4-yloxymethyl-3-(4-(4-(5-cyanopyrid-2-yl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one —— C24H22FN7O3 475.482 —— N-((S)-3-{3-Fluoro-4-[4-(5-formyl-furan-2-ylmethyl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide 392659-24-4 C22H25FN4O5 444.463 —— (5R)-3-{3-fluoro-4-[4-(5-nitro-2-thienyl)piperazin-1-yl]phenyl}-5-[(pyridin-2-yloxy)methyl]-1,3-oxazolidin-2-one —— C23H22FN5O5S 499.523 —— N-((S)-3-{3-Fluoro-4-[4-(5-nitro-thiophen-2-ylmethyl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide —— C21H24FN5O5S 477.516 —— ((5R)-3-{3-fluoro-4-[4-(5-nitro-2-thienyl)piperazin-1-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl (phenylsulfonyl)carbamate —— C25H24FN5O8S2 605.625 - 1
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反应信息
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作为反应物：