clarithromycin 9(E)-oxime | 127253-06-9

物质功能分类

分析化学 - 标准品 - 药典标准品和杂质标准品

分子结构分类

有机化合物 - 有机氧化合物

中文名称

——

中文别名

——

英文名称

clarithromycin 9(E)-oxime

英文别名

Clarithromycin 9-Oxime；(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-10-hydroxyimino-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one

CAS

127253-06-9

化学式

C₃₈H₇₀N₂O₁₃

mdl

——

分子量

762.979

InChiKey

MWBJRTBANFUBOX-SQYJNGITSA-N

BEILSTEIN

——

EINECS

——

物化性质

熔点：

160-163°C
沸点：

827.7±65.0 °C(Predicted)
密度：

1.26
溶解度：

可溶于氯仿（少许）、甲醇（少许）

计算性质

辛醇/水分配系数(LogP)：

3.4
重原子数：

53
可旋转键数：

8
环数：

3.0
sp3杂化的碳原子比例：

0.95
拓扑面积：

198
氢给体数：

5
氢受体数：

15

SDS

SDS：cff768e0c0bd4d10f6feb0b4a676c998

查看

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
克拉霉素	clarithromycin	81103-11-9	C₃₈H₆₉NO₁₃	747.965
——	6-0-methylerythromycin A	——	C₃₈H₆₉NO₁₃	747.965

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	6-O-methyl Ery A 9(Z)-oxime	127253-05-8	C₃₈H₇₀N₂O₁₃	762.979
——	5-O-desosaminyl-6-O-methylerythronolide A 9-oxime	561327-03-5	C₃₀H₅₆N₂O₁₀	604.782
克拉霉素	clarithromycin	81103-11-9	C₃₈H₆₉NO₁₃	747.965
——	(E)-5-mycaminosyl-3-O-descladinosyl-6-O-methyl-3-oxo-erythronolide A 9-oxime-11,12-cyclic-carbonate	——	C₃₁H₅₂N₂O₁₂	644.76
——	6-O-methyl-9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin A	348125-79-1	C₃₈H₇₂N₂O₁₂	748.996
——	(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-2-ethyl-3,4-dihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl]oxy-10-methoxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one	141882-47-5	C₃₉H₇₄N₂O₁₂	763.023
——	(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-2-ethyl-3,4-dihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl]oxy-10-methoxy-3,5,8,10,12,14-hexamethyl-6-propyl-1-oxa-6-azacyclopentadecan-15-one	1289429-82-8	C₄₁H₇₈N₂O₁₂	791.077
——	(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-6-allyl-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-2-ethyl-3,4-dihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl]oxy-10-methoxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one	1289429-83-9	C₄₁H₇₆N₂O₁₂	789.061
——	6-O-methyl-8a-aza-8a-homoerythromycin A	244606-08-4	C₃₈H₇₀N₂O₁₃	762.979
——	6-O-methyl-9a-aza-9a-homoerythromycin A	210912-02-0	C₃₈H₇₀N₂O₁₃	762.979
——	3'-N-demethyl-4"-O-(2-diethylaminoethanoyl)-6-O-methyl-9a-aza-9a-homoerythromycin A	1236808-83-5	C₄₃H₇₉N₃O₁₄	862.112
——	(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-6-benzyl-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-2-ethyl-3,4-dihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl]oxy-10-methoxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one	1289429-85-1	C₄₅H₇₈N₂O₁₂	839.121
——	(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-N,2-diethyl-3,4-dihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl]oxy-10-methoxy-3,5,8,10,12,14-hexamethyl-15-oxo-1-oxa-6-azacyclopentadecane-6-carboxamide	1289429-87-3	C₄₁H₇₇N₃O₁₃	820.075
——	(E)-5-(4-O-(2-chloroethyl)carbamoyl-mycaminosyl)-3-O-descladinosyl-6-O-methyl-3-oxo-erythronolide A 9-O-((2-chloroethyl)carbamoyl)oxime-11,12-cyclic-carbonate	——	C₃₇H₆₀Cl₂N₄O₁₄	855.808
——	(E)-5-(4-O-pentylcarbamoyl-mycaminosyl)-3-O-descladinosyl-6-O-methyl-3-oxo-erythronolide A 9-O-(pentylcarbamoyl)oxime-11,12-cyclic-carbonate	——	C₄₃H₇₄N₄O₁₄	871.079
——	(E)-5-(4-O-(4-trifluoromethylphenyl)carbamoyl-mycaminosyl)-3-O-descladinosyl-6-O-methyl-3-oxo-erythronolide A 9-oxime-11,12-cyclic-carbonate	——	C₃₉H₅₆F₃N₃O₁₃	831.881
——	(E)-5-(4-O-cyclohexylcarbamoyl-mycaminosyl)-3-O-descladinosyl-6-O-methyl-3-oxo-erythronolide A 9-O-(cyclohexylcarbamoyl)oxime-11,12-cyclic-carbonate	——	C₄₅H₇₄N₄O₁₄	895.101