3-O-(β-D-glucopyranosyl)-4'-O-(6-O-acetyl-β-D-glucosyl)rhamnazin | 1421281-88-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3-O-(β-D-glucopyranosyl)-4'-O-(6-O-acetyl-β-D-glucosyl)rhamnazin
• 英文别名: nerilifordin G；[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[4-[5-hydroxy-7-methoxy-4-oxo-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-yl]-2-methoxyphenoxy]oxan-2-yl]methyl acetate
• CAS: 1421281-88-0
• 化学式: C₃₁H₃₆O₁₈
• 分子量: 696.616
• InChiKey: IXOTVRNTGYHCKB-KXVYOKALSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  49
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  270
• 氢给体数：
  8
• 氢受体数：
  18

反应信息

• 作为反应物：
  描述：

  3-O-(β-D-glucopyranosyl)-4'-O-(6-O-acetyl-β-D-glucosyl)rhamnazin 在 盐酸 作用下， 以 水 为溶剂， 反应 8.0h， 生成 D-glucose
  参考文献：
  名称：

  Five new flavonoid glycosides fromNervilia fordii

  摘要：

  Five new flavonoid glycosides, namely nervilifordins F-J (1-5), were isolated from the 60% EtOH extract of the aerial parts of Nerviliafordii, along with three first isolated flavonoids (7, 8, and 13) and five known flavonoids (6, 9-12). The structures of new compounds were elucidated on the basis of 1D and 2D NMR and MS studies. Their anti-inflammatory activities were tested by measuring their inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages. Compounds 2 and 5 showed interesting inhibition effects with their EC50 values of 15.15M and 14.80M, respectively.

  DOI：

  10.1080/10286020.2013.790377