N'-tert-butyl-N-[7-chloro-3-[3-(trifluoromethoxy)phenyl]quinolin-4-yl]propane-1,3-diamine | 1447160-97-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N'-tert-butyl-N-[7-chloro-3-[3-(trifluoromethoxy)phenyl]quinolin-4-yl]propane-1,3-diamine
• CAS: 1447160-97-5
• 化学式: C₂₃H₂₅ClF₃N₃O
• 分子量: 451.919
• InChiKey: YDSKJLUAOKBDCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] COMPOUNDS, COMPOSITIONS AND ASSOCIATED METHODS COMPRISING 3-ARYL QUINOLINES<br/>[FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS ASSOCIÉS COMPRENANT DES 3-ARYL-QUINOLÉINES
  申请人：UNIV OREGON HEALTH & SCIENCE

  公开号：WO2013106847A1

  公开（公告）日：2013-07-18

  Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and methods of treating infectious diseases such as malaria, are disclosed.

  本发明提供了用于治疗传染性疾病的化合物、组合物和方法。具体地，本发明揭示了3-芳基喹啉化合物、其合成方法、制药组合物以及治疗疟疾等传染性疾病的方法。
• COMPOUNDS, COMPOSITIONS AND ASSOCIATED METHODS COMPRISING 3-ARYL QUINOLINES
  申请人：Oregon Health & Science University

  公开号：US20140350048A1

  公开（公告）日：2014-11-27

  Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and methods of treating infectious diseases such as malaria, are disclosed.

  本发明提供了用于治疗传染病的化合物、组合物和方法。具体地，本发明揭示了3-芳基喹啉化合物、其合成、制药组合物以及治疗疟疾等传染病的方法。
• Compounds, compositions and associated methods comprising 3-aryl quinolines
  申请人：Oregon Health & Science University

  公开号：US10023538B2

  公开（公告）日：2018-07-17

  Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and methods of treating infectious diseases such as malaria, are disclosed.

  本文提供了用于治疗传染病的化合物、组合物和方法。特别是公开了 3-芳基喹啉化合物、其合成、其药物组合物以及治疗疟疾等传染性疾病的方法。
• US9249103B2
  申请人：——

  公开号：US9249103B2

  公开（公告）日：2016-02-02