BLZ945 | 1407593-16-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: BLZ945
• 英文别名: Blz 945; blz-945；4-[[2-[(2-hydroxycyclohexyl)amino]-1,3-benzothiazol-6-yl]oxy]-N-methylpyridine-2-carboxamide
• CAS: 1407593-16-1
• 化学式: C₂₀H₂₂N₄O₃S
• 分子量: 398.486
• InChiKey: ADZBMFGQQWPHMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  丁二酸酐 、 BLZ945 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  CN115969992

  摘要：

  公开号：

文献信息

• CSF-1R INHIBITORS FOR TREATMENT OF BRAIN TUMORS
  申请人：Novartis AG

  公开号：EP2704713B1

  公开（公告）日：2017-01-18
• METHODS FOR TREATING OCULAR DISEASE USING INHIBITORS OF CSF-1R
  申请人：NOVARTIS AG

  公开号：US20190231765A1

  公开（公告）日：2019-08-01

  The present invention provides in one aspect methods for treating ocular diseases by administering pharmaceutical compositions comprising an inhibitor of colony stimulating factor-1 (CSF-1) receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one inhibitor of CSF-1R. The inhibitor can also be a selective inhibitor of CSF-1R in certain embodiments.
• [EN] CSF-1R INHIBITORS FOR TREATMENT OF BRAIN TUMORS<br/>[FR] INHIBITEURS DE CSF-1R POUR TRAITEMENT DE TUMEURS CÉRÉBRALES
  申请人：NOVARTIS AG

  公开号：WO2012151523A1

  公开（公告）日：2012-11-08

  The present invention provides a compound of formula I; where in R1 is an alkyl pyrazole or an alkyl carboxamide, and R2 is a hydroxycycloalkyl; or a pharmaceutically acceptable salt thereof, and compositions containing these compounds, for use to treat a brain tumor, particularly glioblastoma. The invention provides effective treatment of a brain tumor and can be used by oral administration of a compound of Formula I as further described herein. Gene signatures correlated with successful treatment using these methods are also disclosed.
• [EN] CSF-1R INHIBITORS FOR TREATMENT OF BRAIN TUMORS<br/>[FR] INHIBITEURS DE CSF-1R POUR LE TRAITEMENT DE TUMEURS CÉRÉBRALES
  申请人：NOVARTIS AG

  公开号：WO2012151541A1

  公开（公告）日：2012-11-08

  The present invention provides a compound of formula (I) wherein R1 is an alkyl pyrazole or an alkyl carboxamide, and R2 is a hydroxycycloalkyl; or a pharmaceutically acceptable salt thereof, and compositions containing these compounds, for use to treat a brain tumor, particularly glioblastoma. The invention provides effective treatment of a brain tumor and can be used by oral administration of a compound of Formula (I) as further described herein.