2-[(4aS,4bR,5S,6aS,6bR,9aS,10aS,10bS,12S)-8-(4-chloro-phenyl)-4b,12-difluoro-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,8,9,9a,10,10a,10b,11,12-tetradecahydro-7-oxa-8-aza-pentaleno[2,1-a]phenanthren-6b-yl]-2-oxo-ethyl methylcarbamate | 1579137-38-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 2-[(4aS,4bR,5S,6aS,6bR,9aS,10aS,10bS,12S)-8-(4-chloro-phenyl)-4b,12-difluoro-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,8,9,9a,10,10a,10b,11,12-tetradecahydro-7-oxa-8-aza-pentaleno[2,1-a]phenanthren-6b-yl]-2-oxo-ethyl methylcarbamate
• 英文别名: methylcarbamate 2-[(4aS,4bR,5S,6aS,6bR,9aS,10aS,10bS,12S)-8-(4-chlorophenyl)-4b,12-difluoro-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,8,9,9a,10,10a,10b,11,12-tetradecahydro-7-oxa-8-azapentaleno[2,1-a]phenanthren-6b-yl]-2-oxoethyl ester；[2-[(1S,2S,4S,8R,9S,11S,12R,13S,19S)-6-(4-chlorophenyl)-12,19-difluoro-11-hydroxy-9,13-dimethyl-16-oxo-7-oxa-6-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl] N-methylcarbamate
• CAS: 1579137-38-4
• 化学式: C₃₀H₃₃ClF₂N₂O₆
• 分子量: 591.052
• InChiKey: VIZZAPSLPUVFAX-QSYKFLSHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  41
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• ISOXAZOLIDINE DERIVATIVES
  申请人：Chiesi farmaceutici S.p.A.

  公开号：US20140069419A1

  公开（公告）日：2014-03-13

  Glucocorticosteroids that are derivatives of isoxazolidine are useful as anti-inflammatory and antiallergic compounds of the glucocorticosteroid series.

  以异噁唑啉为衍生物的糖皮质激素是糖皮质激素系列中的抗炎和抗过敏化合物。
• [EN] ISOXAZOLIDINE DERIVATIVES<br/>[FR] DÉRIVÉS ISOXAZOLIDINE
  申请人：CHIESI FARMA SPA

  公开号：WO2014040837A1

  公开（公告）日：2014-03-20

  The present invention relates to novel anti-inflammatory and antiallergic compounds of the glucocorticosteroid series, methods of preparing such compounds, pharmaceutical compositions comprising them, combinations and therapeutic uses thereof. More particularly, the invention relates to glucocorticosteroids that are derivatives of isoxazolidine.

  本发明涉及一种新型的糖皮质激素系列的抗炎和抗过敏化合物，制备这种化合物的方法，包含它们的药物组合物以及它们的治疗用途。更具体地，本发明涉及的是异噁唑啉衍生物的糖皮质激素。
• US9155747B2
  申请人：——

  公开号：US9155747B2

  公开（公告）日：2015-10-13
• US9469669B2
  申请人：——

  公开号：US9469669B2

  公开（公告）日：2016-10-18