N³-((3R,7R,11R)-7,11-bis(2,3-dihydroxybenzamido)-2,6,10-trioxo-1,5,9-trioxacyclodo-decan-3-yl)-N¹-(1-cyclohexyl-1-oxo-5,8,11-trioxa-2-azatridecan-13-yl)-4,5-dihydroxyiso-phthalamide | 1407510-76-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N³-((3R,7R,11R)-7,11-bis(2,3-dihydroxybenzamido)-2,6,10-trioxo-1,5,9-trioxacyclodo-decan-3-yl)-N¹-(1-cyclohexyl-1-oxo-5,8,11-trioxa-2-azatridecan-13-yl)-4,5-dihydroxyiso-phthalamide
• CAS: 1407510-76-2
• 化学式: C₄₆H₅₅N₅O₂₀
• 分子量: 997.964
• InChiKey: VXJFFJKBIHAYLI-XWHIBYANSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.26
• 重原子数：
  71.0
• 可旋转键数：
  20.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  373.47
• 氢给体数：
  11.0
• 氢受体数：
  20.0

反应信息

• 作为产物：
  描述：

  在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 、 乙酸乙酯 为溶剂， 反应 6.0h， 以27%的产率得到N³-((3R,7R,11R)-7,11-bis(2,3-dihydroxybenzamido)-2,6,10-trioxo-1,5,9-trioxacyclodo-decan-3-yl)-N¹-(1-cyclohexyl-1-oxo-5,8,11-trioxa-2-azatridecan-13-yl)-4,5-dihydroxyiso-phthalamide
  参考文献：
  名称：

  Siderophore-Mediated Cargo Delivery to the Cytoplasm of Escherichia coli and Pseudomonas aeruginosa: Syntheses of Monofunctionalized Enterobactin Scaffolds and Evaluation of Enterobactin–Cargo Conjugate Uptake

  摘要：

  The design and syntheses of monofunctionalized enterobactin (Ent, L- and D-isomers) scaffolds where one catecholate moiety of enterobactin houses an alkene, aldehyde, or carboxylic acid at the C5 position are described. These molecules are key precursors to a family of 10 enterobactin-cargo conjugates presented in this work, which were designed to probe the extent to which the Gram-negative ferric enterobactin uptake and processing machinery recognizes, transports, and utilizes derivatized enterobactin scaffolds. A series of growth recovery assays employing enterobactin-deficient E. coli ATCC 33475 (ent-) revealed that six conjugates based on L-Ent having relatively small cargos promoted E. coli growth under iron limiting conditions whereas negligible-to-no growth recovery was observed for four conjugates with relatively large cargos. No growth recovery was observed for the enterobactin receptor deficient strain of E. coli H1187 (fepA-) or the enterobactin esterase deficient derivative of E. coli K-12 JW0576 (fes-), or when the D-isomer of enterobactin was employed These results demonstrate that the E. coli ferric enterobactin transport machinery identifies and delivers select cargo-modified scaffolds to the E. coli cytoplasm. Pseudomonas aeruginosa PAO1 K648 (pvd-, pch-) exhibited greater promiscuity than that of E. coli for the uptake and utilization of the enterobactin-cargo conjugates, and growth promotion was observed for eight conjugates under iron-limiting conditions. Enterobactin may be utilized for delivering molecular cargos via its transport machinery to the cytoplasm of E. coli and P. aeruginosa thereby providing a means to overcome the Gram-negative outer membrane permeability barrier.

  DOI：

  10.1021/ja3077268