Pt-L6-NH2 | 172902-96-4

• 英文名称: Pt-L6-NH2
• 英文别名: Pt-L₆-NH₂
• CAS: 172902-96-4
• 化学式: C₆H₂₂ClN₄Pt
• 分子量: 380.8
• InChiKey: YXNMIOSFTUEKRS-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  Pt-L6-NH2 、 β-Ala-Py-L₄-Im 在 2-(1H-benzotriazole-1-yL)-1,1,3,3-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.08h， 以72.9%的产率得到[Cl(NH3)2Pt-L6-β-Ala-Py-L4-Im]Cl*H2O
  参考文献：
  名称：

  Synthesis and characterisation of metallopolyamide complexes

  摘要：

  Platinum(II) and ruthenium(II)-based complexes that contain imidazole, pyrrole and beta-alanine subunits, capable of recognising specific DNA base-pair sequences, have been synthesised. These polyamides, two platinum(II), [Cl(NH3)(2)Pt-L-6-beta-Ala-Py-L-4-Im](+) (HSP-2), and [Cl(NH3)(2)Pt-L-6-beta-Ala-PyPyPy-L-4-ImImIm](+) (HSP-6) and two ruthenium, Delta and Lambda-[beta-Ala-Py-L-4-Im-beta-dpq-Ru(phen)(2)](2+) (Delta and Lambda-RUP1), were designed to recognise DNA sequences up to seven base-pairs in length. They were obtained in good yield by a combination of solid and solution phase chemistries. The chirality of the ruthenium precursors Delta- and Lambda-[Ru(phen)(2)(phendo)](2+) was conserved throughout the synthesis. Characterisation was achieved using NMR, UV-Vis and ESI-MS and CD for Delta- and Lambda-RUP1. Cytotoxicity was not determined for HSP-2 or HSP-6, due to insolubility, however the IC50 values of Delta and Lambda-RUP1 were confirmed to be greater than 40 mu M (at an incubation time of 48 h). LD studies indicated that the ruthenium complexes interact with ct-DNA through a mixed binding mode, which is influenced by complex concentration and chirality. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.06.013
• 作为产物：
  描述：

  Pt-L₆-NH.Boc 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 48.0h， 以87%的产率得到Pt-L6-NH2
  参考文献：
  名称：

  Synthesis and characterisation of metallopolyamide complexes

  摘要：

  Platinum(II) and ruthenium(II)-based complexes that contain imidazole, pyrrole and beta-alanine subunits, capable of recognising specific DNA base-pair sequences, have been synthesised. These polyamides, two platinum(II), [Cl(NH3)(2)Pt-L-6-beta-Ala-Py-L-4-Im](+) (HSP-2), and [Cl(NH3)(2)Pt-L-6-beta-Ala-PyPyPy-L-4-ImImIm](+) (HSP-6) and two ruthenium, Delta and Lambda-[beta-Ala-Py-L-4-Im-beta-dpq-Ru(phen)(2)](2+) (Delta and Lambda-RUP1), were designed to recognise DNA sequences up to seven base-pairs in length. They were obtained in good yield by a combination of solid and solution phase chemistries. The chirality of the ruthenium precursors Delta- and Lambda-[Ru(phen)(2)(phendo)](2+) was conserved throughout the synthesis. Characterisation was achieved using NMR, UV-Vis and ESI-MS and CD for Delta- and Lambda-RUP1. Cytotoxicity was not determined for HSP-2 or HSP-6, due to insolubility, however the IC50 values of Delta and Lambda-RUP1 were confirmed to be greater than 40 mu M (at an incubation time of 48 h). LD studies indicated that the ruthenium complexes interact with ct-DNA through a mixed binding mode, which is influenced by complex concentration and chirality. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.06.013