(E)-methyl 2-(2-(4-methoxyphenyl)hydrazono)acetate | 1450909-01-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-methyl 2-(2-(4-methoxyphenyl)hydrazono)acetate
• CAS: 1450909-01-9
• 化学式: C₁₀H₁₂N₂O₃
• 分子量: 208.217
• InChiKey: JQPORJCGLBZPLM-YRNVUSSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.27
• 重原子数：
  15.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  59.92
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  (E)-methyl 2-(2-(4-methoxyphenyl)hydrazono)acetate 、 苄叉丙酮 在 (S)-N¹-cyclohexyl-3,3-dimethylbutane-1,2-diamine 、 邻氟苯甲酸 作用下， 反应 72.0h， 以55%的产率得到(R)-methyl 1-(4-methoxyphenyl)-6-methyl-4-phenyl-1,4-dihydropyridazine-3-carboxylate
  参考文献：
  名称：

  Catalytic Asymmetric Construction of Chiral Hydropyridazines via Conjugate Addition of N-Monosubstituted Hydrazones to Enones

  摘要：

  The first example of a highly enantioselective and scalable formal diaza-ene reaction between N-monosubstituted hydrazones and enones catalyzed by a simple chiral primary-second diamine salt has been developed. The catalytic process provides a highly practical and stereoselective synthetic method for chiral hydropyridazines.

  DOI：

  10.1021/ol4020865
• 作为产物：
  描述：

  乙醛酸甲酯 、 4-甲氧基苯肼盐酸盐 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以73%的产率得到(E)-methyl 2-(2-(4-methoxyphenyl)hydrazono)acetate
  参考文献：
  名称：

  Catalytic Asymmetric Construction of Chiral Hydropyridazines via Conjugate Addition of N-Monosubstituted Hydrazones to Enones

  摘要：

  The first example of a highly enantioselective and scalable formal diaza-ene reaction between N-monosubstituted hydrazones and enones catalyzed by a simple chiral primary-second diamine salt has been developed. The catalytic process provides a highly practical and stereoselective synthetic method for chiral hydropyridazines.

  DOI：

  10.1021/ol4020865