4-Methoxy-8-(1-methylethyl)-2-quinolinecarboxylic acid | 1204345-68-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-Methoxy-8-(1-methylethyl)-2-quinolinecarboxylic acid
• 英文别名: 4-methoxy-8-propan-2-ylquinoline-2-carboxylic acid
• CAS: 1204345-68-5
• 化学式: C₁₄H₁₅NO₃
• 分子量: 245.27
• InChiKey: OVWXNOAFGDXEQX-UHFFFAOYSA-N

物化性质

• 沸点：
  374.6±37.0 °C(Predicted)
• 密度：
  1.205±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SUBSTITUTED INDOLE MCL-1 INHIBITORS
  申请人：Vanderbilt University

  公开号：US20210283138A1

  公开（公告）日：2021-09-16

  The present disclosure provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present disclosure also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.