4-Amino-5-(1-hydroxy-ethyl)-2-(2-morpholin-4-yl-ethyl)-6-phenyl-2H-pyridazin-3-one | 681829-03-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Amino-5-(1-hydroxy-ethyl)-2-(2-morpholin-4-yl-ethyl)-6-phenyl-2H-pyridazin-3-one
• CAS: 681829-03-8
• 化学式: C₁₈H₂₄N₄O₃
• 分子量: 344.414
• InChiKey: NELNQZIBIIOZCK-UHFFFAOYSA-N

物化性质

• 沸点：
  531.8±60.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.88
• 重原子数：
  25.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  93.61
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  4-Amino-5-(1-hydroxy-ethyl)-2-(2-morpholin-4-yl-ethyl)-6-phenyl-2H-pyridazin-3-one 在 PPA 作用下， 以42%的产率得到4-Amino-2-(2-morpholin-4-yl-ethyl)-6-phenyl-5-vinyl-2H-pyridazin-3-one
  参考文献：
  名称：

  4-Amino-3(2H)-pyridazinones bearing arylpiperazinylalkyl groups and related compounds: synthesis and antinociceptive activity

  摘要：

  A series of 4-amino-3(2H)-pyridazinones substituted at position 2 with arylpiperazinylalkyl groups and analogues were synthesized and their antinociceptive effect was evaluated in the mouse abdominal constriction model. Preliminary SARs studies were performed. Several of the novel compounds dosed at 100 mg/kg s.c. significantly reduced the number of writhes induced by the noxious stimulus. Compound 12e showed 100% inhibition of writhes and was able to protect all the treated animals from the effect of the chemical stimulus. Subsequent dose-response studies revealed 12e to be almost 40-fold more potent than the structurally related Emorfazone.

  DOI：

  10.1016/s0014-827x(03)00162-9
• 作为产物：
  描述：

  6-(2-Bromo-ethyl)-3-methyl-4-phenyl-6H-isoxazolo[3,4-d]pyridazin-7-one 在 palladium on activated charcoal sodium tetrahydroborate 、 一水合肼 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 1.0h， 生成 4-Amino-5-(1-hydroxy-ethyl)-2-(2-morpholin-4-yl-ethyl)-6-phenyl-2H-pyridazin-3-one
  参考文献：
  名称：

  4-Amino-3(2H)-pyridazinones bearing arylpiperazinylalkyl groups and related compounds: synthesis and antinociceptive activity

  摘要：

  A series of 4-amino-3(2H)-pyridazinones substituted at position 2 with arylpiperazinylalkyl groups and analogues were synthesized and their antinociceptive effect was evaluated in the mouse abdominal constriction model. Preliminary SARs studies were performed. Several of the novel compounds dosed at 100 mg/kg s.c. significantly reduced the number of writhes induced by the noxious stimulus. Compound 12e showed 100% inhibition of writhes and was able to protect all the treated animals from the effect of the chemical stimulus. Subsequent dose-response studies revealed 12e to be almost 40-fold more potent than the structurally related Emorfazone.

  DOI：

  10.1016/s0014-827x(03)00162-9