2'-O-(tert-butyldimethylsilyl)inosine 3'-(allyl 2-cyanoethylphosphate) | 1255515-81-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核糖核苷3'-磷酸盐
• 英文名称: 2'-O-(tert-butyldimethylsilyl)inosine 3'-(allyl 2-cyanoethylphosphate)
• CAS: 1255515-81-1
• 化学式: C₂₂H₃₄N₅O₈PSi
• 分子量: 555.6
• InChiKey: JFLBLEKNLIEPLA-BYEFOFRESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.44
• 重原子数：
  37.0
• 可旋转键数：
  12.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  171.07
• 氢给体数：
  2.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  2'-O-(tert-butyldimethylsilyl)-5'-O (p,p'-dimethoxytrityl)inosine 3'-[(2-cyanoethyl)N,N-diisopropylaminophosphoramidite] 、 2'-O-(tert-butyldimethylsilyl)inosine 3'-(allyl 2-cyanoethylphosphate) 在 1H-imidazole perchlorate 作用下， 以 乙腈 为溶剂， 反应 1.25h， 生成
  参考文献：
  名称：

  Synthesis of cyclic di-nucleotidic acids as potential inhibitors targeting diguanylate cyclase

  摘要：

  Five analogs of cyclic di-nucleotidic acid including c-di-GMP were synthesized and evaluated for their biological activities on Slr1143, a diguanylate cyclase of Synechocystis sp. Slr1143 was overexpressed from the recombinant plasmid which contained the gene of interest and subsequently purified by affinity chromatography. A new HPLC method capable of separating the compound and product peaks with good resolution was optimized and applied to the analysis of the compounds. Results obtained show that cyclic di-inosinylic acid 1b demonstrates a stronger inhibition on Slr1143 than c-di-GMP and is a potential inhibitor for biofilm formation. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.07.068
• 作为产物：
  描述：

  在 二氯乙酸 、 碳酸氢钠 作用下， 以 二氯甲烷 为溶剂， 生成 2'-O-(tert-butyldimethylsilyl)inosine 3'-(allyl 2-cyanoethylphosphate)
  参考文献：
  名称：

  Synthesis of cyclic di-nucleotidic acids as potential inhibitors targeting diguanylate cyclase

  摘要：

  Five analogs of cyclic di-nucleotidic acid including c-di-GMP were synthesized and evaluated for their biological activities on Slr1143, a diguanylate cyclase of Synechocystis sp. Slr1143 was overexpressed from the recombinant plasmid which contained the gene of interest and subsequently purified by affinity chromatography. A new HPLC method capable of separating the compound and product peaks with good resolution was optimized and applied to the analysis of the compounds. Results obtained show that cyclic di-inosinylic acid 1b demonstrates a stronger inhibition on Slr1143 than c-di-GMP and is a potential inhibitor for biofilm formation. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.07.068