(R)-1-({6-[(2,5-dihydroxybenzyl)amino]-9-isopropyl-9H-purin-2-yl}amino)propan-2-ol | 1257693-58-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: (R)-1-({6-[(2,5-dihydroxybenzyl)amino]-9-isopropyl-9H-purin-2-yl}amino)propan-2-ol
• 英文别名: 2-[[[2-[[(2R)-2-hydroxypropyl]amino]-9-propan-2-ylpurin-6-yl]amino]methyl]benzene-1,4-diol
• CAS: 1257693-58-5
• 化学式: C₁₈H₂₄N₆O₃
• 分子量: 372.427
• InChiKey: NUBKBHURWPTBMW-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  128
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• [EN] SUBSTITUTED 6-(2-HYDROXYBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THESE DERIVATIVES<br/>[FR] DÉRIVÉS DE 6-(2-HYDROXYBENZYLAMINO)PURINE SUBSTITUÉS, LEUR UTILISATION EN TANT QUE MÉDICAMENTS ET COMPOSITIONS CONTENANT CES DÉRIVÉS
  申请人：UNIV PALACKEHO

  公开号：WO2010139289A1

  公开（公告）日：2010-12-09

  The invention relates to substituted 6-(2-hydroxybenzylamino)purines of general formula I, to their activity as cyclin-dependent kinases 2, 5, 7 and 9 inhibitors and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation or inflammation. The invention further includes pharmaceutical compositions containing the substituted 6-(2-hydroxybenzylamino)purines.

  本发明涉及一般式I的取代6-(2-羟基苯基氨基)嘌呤，以及它们作为细胞周期素依赖性激酶2、5、7和9的抑制剂的活性，以及作为药物，特别是在治疗涉及细胞增殖或炎症的疾病中的用途。本发明还包括含有取代的6-(2-羟基苯基氨基)嘌呤的制药组合物。
• Substituted 6-(2-hydroxybenzylamino)purine Derivatives, Their Use as Medicaments and Compositions Containing These Derivatives
  申请人：Zatloukal Marek

  公开号：US20120070512A1

  公开（公告）日：2012-03-22

  The invention relates to substituted 6-(2-hydroxybenzylamino)purines of general formula I, to their activity as cyclin-dependent kinases 2, 5, 7 and 9 inhibitors and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation or inflammation. The invention further includes pharmaceutical compositions containing the substituted 6-(2-hydroxybenzylamino)purines.

  本发明涉及一般式I的取代6-(2-羟基苯基氨基)嘌呤，其作为周期素依赖性激酶2、5、7和9的抑制剂的活性以及它们在药物治疗中的使用，特别是在涉及细胞增殖或炎症的疾病治疗中。本发明还包括含有取代6-(2-羟基苯基氨基)嘌呤的药物组合物。
• SUBSTITUTED 6-(2-HYDROXYBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THESE DERIVATIVES
  申请人：Univerzita Palackého v Olomouci

  公开号：EP2438068A1

  公开（公告）日：2012-04-11
• US8492391B2
  申请人：——

  公开号：US8492391B2

  公开（公告）日：2013-07-23