2-N-methylcarbamoyloxymethyl-6-methyl-4-(m-nitrophenyl)-3,5-diethoxycarbonyl-1,4-dihydropyridine | 84126-88-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-N-methylcarbamoyloxymethyl-6-methyl-4-(m-nitrophenyl)-3,5-diethoxycarbonyl-1,4-dihydropyridine
• 英文别名: 2-N-methylaminocarbonyloxymethyl-6-methyl-4-(3-nitrophenyl)-3,5-diethoxycarbonyl-1,4-dihydropyridine；Diethyl 2-methyl-6-(methylcarbamoyloxymethyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• CAS: 84126-88-5
• 化学式: C₂₁H₂₅N₃O₈
• 分子量: 447.445
• InChiKey: PGNHWIHDBCGMAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  149
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• 2-Substituted or unsubstituted aminocarbonyloxyalkyl-1,4-dihydropyridines
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0063747A1

  公开（公告）日：1982-11-03

  Novel compounds having vasodilation and hypotensive effects are represented by the formula where R' is halogen, nitro, cyano or lower alkoxy; each of R2 and R3 is lower alkyl, lower haloalkyl, lower alkoxyalkyl, aralkyloxyalkyl, aryloxyalkyl, lower alkenoxyalkyl, N,N-di-lower alkylaminoalkyl, N-lower alkyl-N-aralkylaminoalkyl, piperidylalkyl, 4-lower alkyl piperazinylalkyl, norpholinoalkyl or 1-pyrrolidinylalkyl; R' is lower alkyl; A is lower alkylene; and R5 is hydrogen, lower alkyl, cycloalkyl of 3 to 7 carbon atoms, or aryl unsubstituted or substituted by one or two substituents selected from halogen, nitro, lower alkyl, lower alkoxy, di-lower alkylamino and cyano. Also disclosed are processes for their preparation.

  具有血管扩张和降血压作用的新型化合物由式表示 其中 R'为卤素、硝基、氰基或低级烷氧基；R2 和 R3 分别为低级烷基、低级卤代烷基、低级烷氧基烷基、芳氧基烷基、芳氧基烷基、低级烯氧基烷基、N,N-二低级烷基氨基烷基、N-低级烷基-N-芳基氨基烷基、哌啶基烷基、4-低级烷基哌嗪基烷基、去甲酚基烷基或 1-吡咯烷基烷基；R' 是低级烷基；A 是低级亚烷基；R5 是氢、低级烷基、3 至 7 个碳原子的环烷基或未取代的芳基，或被选自卤素、硝基、低级烷基、低级烷氧基、二低级烷基氨基和氰基的一个或两个取代基取代的芳基。 还公开了其制备工艺。
• Process for preparing 2-carbamoyloxyalkyl-1,4-dihydropyridine derivatives and intermediates useful for the process
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0101023A1

  公开（公告）日：1984-02-22

  A process for preparing a 2-carbamoyloxyalkyl-1,4-dihydropyridine derivative represented by the general formula: which comprises: (a) reacting a 3-amino-3-carbamoyloxyalkylacrylic acid derivative represented by the general formula: with a benzylidene compound represented by the general formula: (b) reacting the 3-amino-3-carbamoyloxyalkylacrylic acid derivative of the general formula II with an aldehyde comoound reoresented bv the aeneral formula: and a β-keto-ester compound represented by the general formula: (c) reacting a 3-carbamoyloxyalkylpropiolic acid derivative represented by the general formula: with the benzylidene compound of the general formula III and ammonia or its salt: or (d) reacting the 3-carbamoyloxyalkylpropiolic acid derivative of the general formula VI with the aldehyde compound of the general formula IV, the β-keto-ester compound of the general formula V and ammonia or its salt, and the intermediates of formula II and VI.

  一种制备通式为 2-氨基甲酰氧基烷基-1,4-二氢吡啶衍生物的工艺： 其中包括 (a) 将通式为 3-氨基-3-氨基甲酰氧基烷基丙烯酸衍生物与通式为 与通式代表的亚苄基化合物反应： (b) 将通式 II 的 3-氨基-3-氨基甲酰氧基烷基丙烯酸衍生物与通式......代表的醛化合物和通式......代表的β-酮酯化合物反应： 和通式代表的 β-酮酯化合物反应： (c) 将通式代表的 3-氨基甲酰氧基烷基丙炔酸衍生物与通式代表的 β-酮酯化合物反应： 与通式 III 的亚苄基化合物和氨或其盐反应：或 (d) 将通式 VI 的 3-氨基甲酰氧基烷基丙炔酸衍生物与通式 IV 的醛化合物、通式 V 的 β-酮酯化合物和氨或其盐以及通式 II 和 VI 的中间产物反应。
• US4404378A
  申请人：——

  公开号：US4404378A

  公开（公告）日：1983-09-13
• US4739106A
  申请人：——

  公开号：US4739106A

  公开（公告）日：1988-04-19
• US4914227A
  申请人：——

  公开号：US4914227A

  公开（公告）日：1990-04-03