bis(μ-(1-methylcytosinato-N3,N4))-bis(cis-diammineplatinum(II))dinitrate | 75936-23-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: bis(μ-(1-methylcytosinato-N3,N4))-bis(cis-diammineplatinum(II))dinitrate
• CAS: 75936-23-1
• 化学式: C₁₀H₂₄N₁₀O₂Pt₂*2NO₃
• 分子量: 830.536
• InChiKey: JCWGNAZEWVWZBR-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  bis(μ-(1-methylcytosinato-N3,N4))-bis(cis-diammineplatinum(II))dinitrate 在 potassium cyanide 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Reaction of cyanide with platinum-nucleobase complexes: preparative, spectroscopic, and structural studies. Unexpected stability of platinum-thymine and platinum-uracil complexes

  摘要：

  DOI：

  10.1021/ic00209a022
• 作为产物：
  描述：

  在 NaOH 作用下， 以 水 为溶剂， 生成 bis(μ-(1-methylcytosinato-N3,N4))-bis(cis-diammineplatinum(II))dinitrate
  参考文献：
  名称：

  Platinum(II) complexes with terminal hydroxo and aqua groups: crystal structures of hydroxo-cis-diammine(1-methylcytosine-N3)platinum(II) nitrate dihydrate, [Pt(OH)(NH3)2(C5H7N3O)]NO3.2H2O, and cis-diammineaqua(1-methylcytosine-N3)platinum(II) dinitrate hydrate, [Pt(NH3)2(H2O)(C5H7N3O)](NO3)2.H2O

  摘要：

  DOI：

  10.1021/ic00135a045

文献信息

• Diplatinum(III) complexes with bridging 1-methylcytosinate ligands and variable axial ligands, including guanine nucleobases
  作者：Gunnar Kampf、Michael Willermann、Eva Freisinger、Bernhard Lippert

  DOI：10.1016/s0020-1693(01)00741-1

  日期：2002.3

  A series of diplatinum(ill) complexes derived from cis-(NH3)(2)Pt" and the model nucleobase 1-methylcytosine (1-MeC) has been prepared and X-ray structurally characterized, all of which contain two anionic base ligands (1-MeC-) in a head-tail (ht).J2Pt(l_MeC -N3.JV4)2Pt(NH -HN0 ',.3H,O (2b), ht-cis+NO,) (NH,)2 Pt(l- arrangement: ht-cis+0NO,)(NH3 3)2(ONO,)](NO3)' MeC -N3,N4)(2)Pt(NH3)(2)(OH2)](ClO4)(3).3.5H(2)O (3), ht-cis-[(OH2)(NH3)(2)Pt(1-MeC-.N3,N4)(2)Pt(NH3)(2)(OH2)](ClO4)(4).H2O (4b), and ht-cis-[(9-EtGH-N7)(NH3)(2)Pt(1-MeC-.N3,N4)(2)Pt (NH3)(2)(9-EtGH-N7)](NO3)(4).9H(2)O (7b) (9-EtGH=9-ethylguanine). Several other compounds, differing in the nature of the axial ligands, have been isolated and or observed in solution by H-1 and Pt-195 NMR spectroscopy. The chemistry of these diplatinum(III) compounds is dominated by facile substitution reactions of the axial ligands. Of particular interest in this context is the ready reaction of 2b or 3 with guanine nucleobases. Since similar compounds are not obtained with any of the other common nucleobases, 2b and 3 can be considered guanine-specific chemical probes. C 2002 Elsevier Science B.V. All rights reserved.
• Faggiani; Lippert; Lock, Inorganic Chemistry, 1982, vol. 21, # 8, p. 3210 - 3216
  作者：Faggiani、Lippert、Lock

  DOI：——

  日期：——