indocyanine green | 3599-32-4

• 物质功能分类: 原料药 - 诊断用药 - 器官功能检查剂
• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: indocyanine green
• 英文别名: ICG；IC-Green；sodium;4-[(2Z)-2-[7-[1,1-dimethyl-3-(4-sulfonatobutyl)benzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]butane-1-sulfonate
• CAS: 3599-32-4
• 化学式: C₄₃H₄₇N₂O₆S₂*Na
• 分子量: 774.978
• InChiKey: MOFVSTNWEDAEEK-UHFFFAOYSA-M

物化性质

• 熔点：
  235 °C
• 溶解度：
  水中的溶解度为1mg/mL
• LogP：
  -0.290
• 颜色/状态：
  DARK GREEN, BLUE-GREEN, OLIVE BROWN, DARK BLUE, OR BLACK POWDER, SOLN ARE DEEP EMERALD-GREEN IN COLOR
• 气味：
  ODORLESS OR WITH SLIGHT ODOR
• 稳定性/保质期：

  在常温常压下，该物质是稳定的三羰花青类染料，并具有吸湿性。其最大吸收波长为775nm，且具有一定刺激性。

• 分解：
  Decomposes gradually above 200 °C.

计算性质

• 辛醇/水分配系数(LogP)：
  5.37
• 重原子数：
  54
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  137
• 氢给体数：
  0
• 氢受体数：
  7

ADMET

代谢

...靛蓝绿...在胆汁中保持不变出现

...INDOCYANINE GREEN...APPEARS IN BILE UNCHANGED

来源:Hazardous Substances Data Bank (HSDB)

代谢

...靛蓝绿...在胆汁中保持不变出现

...INDOCYANINE GREEN...APPEARS IN BILE UNCHANGED

来源:Hazardous Substances Data Bank (HSDB)

代谢

...靛蓝绿...在胆汁中保持不变

...INDOCYANINE GREEN...APPEARS IN BILE UNCHANGED

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 在妊娠和哺乳期间的影响

◉ 母乳喂养期间使用总结：来自一名患者的数据表明，低剂量的靛青绿皮下给药在母乳中无法检测到。目前没有关于更大剂量静脉注射的数据。在获得更多数据之前，母乳喂养期间应谨慎使用靛青绿，尤其是在哺乳新生儿或早产儿时。 ◉ 对哺乳婴儿的影响：截至修订日期，未找到相关的已发布信息。 ◉ 对泌乳和母乳的影响：截至修订日期，未找到相关的已发布信息。

◉ Summary of Use during Lactation:Data from one patient indicates that a low subcutaneous dose of indocyanine green is not detectable in breastmilk. No data are available on the user of larger intravenous doses. Until more data become available, indocyanine green should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. ◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date. ◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.

来源:Drugs and Lactation Database (LactMed)

毒理性

• 相互作用

在预先使用某些药物后，观察到肝脏排泄功能的增加。例如，已经证明苯巴比妥可以增加血浆中消失和胆汁排泄的靛青绿...靛青绿...

INCR IN HEPATIC EXCRETORY FUNCTION HAS BEEN OBSERVED AFTER PRETREATMENT WITH SOME DRUGS. FOR EXAMPLE, PHENOBARBITAL HAS BEEN DEMONSTRATED TO INCR PLASMA DISAPPEARANCE & BILIARY EXCRETION OF...INDOCYANINE GREEN...

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

抑制胆汁分泌靛蓝绿...通过预先使用SKF 525-A处理，表明这是由于临时效应，而不是对肝内质网的影响。

SUPPRESSION OF BILIARY SECRETION OF INDOCYANINE GREEN...BY PRETREATMENT WITH SKF 525-A WAS SHOWN TO BE DUE TO TEMP EFFECT RATHER THAN TO EFFECT ON HEPATIC ENDOPLASMIC RETICULUM.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

靛蓝绿减少了大鼠肝细胞对哇巴因的初始摄取速率超过50%。数据表明，这种化合物可能通过类似于主动载体介导的运输过程进入肝细胞。

INDOCYANINE GREEN DECR INITIAL RATE OF UPTAKE OF OUABAIN IN RAT LIVER CELLS BY MORE THAN 50%. DATA INDICATE THAT CMPD MAY ENTER LIVER CELLS BY PROCESS SIMILAR TO ACTIVE CARRIER-MEDIATED TRANSPORT.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

在雄性大鼠中，通过静脉注射1.0毫克/千克汞，靛蓝绿抑制了甲基汞的胆汁排泄。

IN MALE RATS INJECTED IV WITH 1.0 MG/KG MERCURY, INDOCYANINE GREEN INHIBITED BILIARY EXCRETION OF METHYLMERCURY.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

跟随静脉注射后，吲哚菁绿迅速与血浆蛋白结合，被肝脏快速从循环中清除，并以未结合形式通过胆汁排出。

FOLLOWING IV INJECTION, INDOCYANINE GREEN IS RAPIDLY BOUND TO PLASMA PROTEIN, QUICKLY REMOVED FROM CIRCULATION BY LIVER, & EXCRETED IN BILE IN UNCONJUGATED FORM.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

使用吲哚菁绿实验表明，大鼠的最大胆汁排泄率（0.065毫克/千克/分钟）高于兔（0.05毫克/千克/分钟）和狗（0.027毫克/千克/分钟）。

WITH INDOCYANINE GREEN, IT HAS BEEN SHOWN THAT RAT HAS HIGHER MAX BILIARY EXCRETION RATE (0.065 MG/KG/MIN) THAN DOES RABBIT (0.05 MG/KG/MIN) OR DOG (0.027 MG/KG/MIN).

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

T/2逐渐增加剂量。正常混种犬和纯种比格犬在清除时间上有显著差异。

T/2 INCR WITH INCR DOSAGE. ... CONSIDERABLE DIFFERENCE HAS BEEN NOTED BETWEEN NORMAL MONGRELS & PUREBRED BEAGLES IN CLEARANCE TIMES.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

大鼠对吲哚氰绿肝脏提取率在1毫克/千克以上剂量时出奇地低。肝脏血流量的变化不会改变清除率。

APPARENT HEPATIC EXTRACTION OF INDOCYANINE GREEN IN RATS WAS SURPRISINGLY LOW @ DOSES ABOVE 1 MG/KG. CHANGES IN HEPATIC BLOOD FLOW WOULD NOT ALTER CLEARANCE.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

静脉注射后，靛氰绿迅速与血浆蛋白结合，被肝脏快速清除，并以未结合形式排入胆汁中。

FOLLOWING IV INJECTION, INDOCYANINE GREEN IS RAPIDLY BOUND TO PLASMA PROTEIN, QUICKLY REMOVED FROM CIRCULATION BY LIVER, & EXCRETED IN BILE IN UNCONJUGATED FORM.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36,S37/39
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• 海关编码：
  32129000
• 危险品运输编号：
  NONH for all modes of transport
• RTECS号：
  DE3150000
• 储存条件：
  请将药品存放在避光、通风干燥的地方，并密封保存。

SDS

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模块 1. 化学品
1.1 产品标识符
: 心脏绿
产品名称
1.2 鉴别的其他方法
Foxgreen
CARDIOGREEN
Indocyanine green
IC Green
1.3 有关的确定了的物质或混合物的用�