Acetic acid (8R,9S,13S,14S,17R)-3-acetoxy-17-chlorocarbonylmethyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester | 110346-09-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Acetic acid (8R,9S,13S,14S,17R)-3-acetoxy-17-chlorocarbonylmethyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester
• CAS: 110346-09-3
• 化学式: C₂₄H₂₉ClO₅
• 分子量: 432.944
• InChiKey: PRBNOPXYXQYZEK-DXSQJRSRSA-N

反应信息

• 作为反应物：
  描述：

  Acetic acid (8R,9S,13S,14S,17R)-3-acetoxy-17-chlorocarbonylmethyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester 在 三氯氧磷 作用下， 以 吡啶 、 乙醚 为溶剂， 生成 3,17β-Diacetoxy-N-(6'-hydroxy-1'-hexyl)-17α-pregna-1,3,5(10)-trien-21-oic acid amide phosphate
  参考文献：
  名称：

  Synthesis of some analogs of estradiol

  摘要：

  As part of a search for estradiol derivatives designed for conjugation to carboxyl or amine functions of anti-cancer agents or suitable derivatives thereof, estradiol analogs with side chains at the C-16 or -17 position were prepared for biological assay. These analogs include several which have a substituted nitrogenous function at C-17. The avidity of some of these analogs for binding to estrogen receptor was found to be of a low order.

  DOI：

  10.1016/0039-128x(85)90037-6
• 作为产物：
  描述：

  ((8R,9S,13S,14S,17R)-3,17-Diacetoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)-acetic acid 在 氯化亚砜 作用下， 生成 Acetic acid (8R,9S,13S,14S,17R)-3-acetoxy-17-chlorocarbonylmethyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester
  参考文献：
  名称：

  Synthesis of some analogs of estradiol

  摘要：

  As part of a search for estradiol derivatives designed for conjugation to carboxyl or amine functions of anti-cancer agents or suitable derivatives thereof, estradiol analogs with side chains at the C-16 or -17 position were prepared for biological assay. These analogs include several which have a substituted nitrogenous function at C-17. The avidity of some of these analogs for binding to estrogen receptor was found to be of a low order.

  DOI：

  10.1016/0039-128x(85)90037-6