N-cyclohexyl-4-ethynylaniline | 1374418-16-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-cyclohexyl-4-ethynylaniline
• CAS: 1374418-16-2
• 化学式: C₁₄H₁₇N
• 分子量: 199.296
• InChiKey: AHYLQFFAZUNEND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  9-溴-10-碘基蒽 、 N-cyclohexyl-4-ethynylaniline 在 copper(l) iodide 、 四(三苯基膦)钯 、 二异丙胺 作用下， 以 甲苯 为溶剂， 反应 12.0h， 以53%的产率得到4-((10-bromoanthracen-9-yl)ethynyl)-N-cyclohexylaniline
  参考文献：
  名称：

  Fluorescent nucleosides with ‘on–off’ switching function, pH-responsive fluorescent uridine derivatives

  摘要：

  We synthesized various pH-responsive fluorescent deoxyuridine derivatives (1a-g). These fluorescent nucleosides exhibited distinctive fluorescence at 470-600 nm in aqueous solvents containing methanol only at acidic to neutral pH values. In particular, 1f exhibited strong fluorescence only at pH range of 3.1-7.2 with a pK(a) of 6.1. Such pH-sensitive fluorescent nucleosides can be used as 'on-off' fluorescence switch for monitoring pH change in biological systems, particularly for cancer cell detection. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.02.092
• 作为产物：
  描述：

  N-cyclohexyl-4-iodoaniline 在 四(三苯基膦)钯 、 四丁基氟化铵 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 3.33h， 生成 N-cyclohexyl-4-ethynylaniline
  参考文献：
  名称：

  Fluorescent nucleosides with ‘on–off’ switching function, pH-responsive fluorescent uridine derivatives

  摘要：

  We synthesized various pH-responsive fluorescent deoxyuridine derivatives (1a-g). These fluorescent nucleosides exhibited distinctive fluorescence at 470-600 nm in aqueous solvents containing methanol only at acidic to neutral pH values. In particular, 1f exhibited strong fluorescence only at pH range of 3.1-7.2 with a pK(a) of 6.1. Such pH-sensitive fluorescent nucleosides can be used as 'on-off' fluorescence switch for monitoring pH change in biological systems, particularly for cancer cell detection. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.02.092

文献信息

• Compositions and Methods for use of CXCL12 in Treatment of Bone Disorders
  申请人：NEW YORK UNIVERSITY

  公开号：US20220000980A1

  公开（公告）日：2022-01-06

  The present invention provides compositions and methods for treating a disease or disorder associated with bone defects or reduced or abnormal bone formation.