(R)-1-Benzyloxymethyl-7-methoxy-1-methyl-1,2-dihydro-naphthalene | 187725-57-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (R)-1-Benzyloxymethyl-7-methoxy-1-methyl-1,2-dihydro-naphthalene
• 英文别名: (1R)-7-methoxy-1-methyl-1-(phenylmethoxymethyl)-2H-naphthalene
• CAS: 187725-57-1
• 化学式: C₂₀H₂₂O₂
• 分子量: 294.393
• InChiKey: ARMZEBJERQCFBD-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R)-1-Benzyloxymethyl-7-methoxy-1-methyl-1,2-dihydro-naphthalene 在 palladium dihydroxide 重铬酸吡啶 、 氢气 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 (R)-(+)-1-formyl-1-methyl-7-methoxy-1,2,3,4-tetrahydronaphthalene
  参考文献：
  名称：

  Enzymatic asymmetrisation of prochiral α,α-disubstituted-malonates and -1,3-propanediols: formal asymmetric syntheses of (−)-aphanorphine and (+)-eptazocine

  摘要：

  Formal asymmetric syntheses of (-)-aphanorphine and (+)-eptazocine are reported via the two key intermediates 3a and 3b obtained in 94-97% ee, from the readily available chirons (R)-5 and (R)-9. Which resulting from enzyme-catalysed asymmetrisation of prochiral alpha,alpha-disubstituted-1,3-propanediols and -malonates respectively. (C) 1997 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(96)00538-1
• 作为产物：
  描述：

  (R)-5-Benzyloxy-4-(3-methoxy-phenyl)-4-methyl-pentanal 在 盐酸 、 silica gel 作用下， 以 二氯甲烷 为溶剂， 生成 (R)-1-Benzyloxymethyl-7-methoxy-1-methyl-1,2-dihydro-naphthalene
  参考文献：
  名称：

  Enzymatic asymmetrisation of prochiral α,α-disubstituted-malonates and -1,3-propanediols: formal asymmetric syntheses of (−)-aphanorphine and (+)-eptazocine

  摘要：

  Formal asymmetric syntheses of (-)-aphanorphine and (+)-eptazocine are reported via the two key intermediates 3a and 3b obtained in 94-97% ee, from the readily available chirons (R)-5 and (R)-9. Which resulting from enzyme-catalysed asymmetrisation of prochiral alpha,alpha-disubstituted-1,3-propanediols and -malonates respectively. (C) 1997 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(96)00538-1

文献信息

• Enzymatic asymmetrisation of prochiral α,α-disubstituted-malonates and -1,3-propanediols: formal asymmetric syntheses of (−)-aphanorphine and (+)-eptazocine
  作者：Antoine Fadel、Philippe Arzel

  DOI：10.1016/s0957-4166(96)00538-1

  日期：1997.2

  Formal asymmetric syntheses of (-)-aphanorphine and (+)-eptazocine are reported via the two key intermediates 3a and 3b obtained in 94-97% ee, from the readily available chirons (R)-5 and (R)-9. Which resulting from enzyme-catalysed asymmetrisation of prochiral alpha,alpha-disubstituted-1,3-propanediols and -malonates respectively. (C) 1997 Elsevier Science Ltd. All rights reserved.