5-Ethyl-1-methyl-3-(4-methylphenyl)pyrazole | 943988-63-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Ethyl-1-methyl-3-(4-methylphenyl)pyrazole
• CAS: 943988-63-4
• 化学式: C₁₃H₁₆N₂
• 分子量: 200.283
• InChiKey: PAPAPZXQTUWSPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-(4-methylphenyl)pentane-1,3-dione 、 甲基肼 反应 3.0h， 生成 3-Ethyl-1-methyl-5-(4-methylphenyl)pyrazole 、 5-Ethyl-1-methyl-3-(4-methylphenyl)pyrazole
  参考文献：
  名称：

  WO2007/79130

  摘要：

  公开号：

文献信息

• Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides
  申请人：Miao Zhenwei

  公开号：US20090240029A1

  公开（公告）日：2009-09-24

  Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one heterocycle, aldol-based, dicarbonyl, and/or diamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one heterocycle, aldol-based, dicarbonyl, and/or diamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

  本文披露了非天然氨基酸和多肽，其中包括至少一个非天然氨基酸，以及制备这种非天然氨基酸和多肽的方法。这些非天然氨基酸本身或作为多肽的一部分，可以包括各种可能的功能，但通常至少具有一个杂环，醛缩基，二羰基和/或二胺基团。本文还披露了经翻译后进一步修饰的非天然氨基酸多肽，以及实现这种修饰的方法和纯化这种多肽的方法。通常，修饰后的非天然氨基酸多肽包括至少一个杂环，醛缩基，二羰基和/或二胺基团。此外，还披露了使用这种非天然氨基酸多肽和经修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。
• [EN] COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES<br/>[FR] ACIDES AMINÉS ET POLYPEPTIDES NON NATURELS, COMPOSITIONS CONTENANT CEUX-CI, PROCÉDÉS METTANT EN JEU CEUX-CI ET UTILISATIONS DE CEUX-CI
  申请人：AMBRX INC

  公开号：WO2007079130A2

  公开（公告）日：2007-07-12

  [EN] Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one heterocycle, aldol-based, dicarbonyl, and/or diamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one heterocycle, aldol-based, dicarbonyl, and/or diamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
  [FR] L'invention concerne des acides aminés non naturels et des polypeptides qui comprennent au moins un acide aminé non naturel et des procédés servant à fabriquer de tels acides aminés et polypeptides non naturels. Les acides aminés non naturels, par eux-mêmes ou en tant que partie d'un polypeptide, peuvent comprendre une large palette de fonctionnalités possibles, mais ils ont généralement au moins un groupe hétérocyclique, à base d'aldol, dicarbonyle et/ou diamine. L'invention concerne également des polypeptides d'acides aminés non naturels qui sont en plus modifiés de façon post-traductionnelle, des procédés servant à effectuer de telles modifications et des procédés servant à purifier de tels polypeptides. Généralement, les polypeptides d'acides aminés non naturels comprennent au moins un groupe hétérocyclique, à base d'aldol, dicarbonyle et/ou diamine. L'invention concerne en outre des procédés d'utilisation de tels polypeptides d'acides aminés non naturels et de polypeptides d'acides aminés non naturels modifiés, dont des utilisations thérapeutiques, de diagnostic et d'autres utilisations en biotechnologie.