1-Oxyl-2,2,6,6-tetramethyl-4-glycidyloxypiperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-Oxyl-2,2,6,6-tetramethyl-4-glycidyloxypiperidine
• 英文别名: 1-hydroxy-2,2,6,6-tetramethyl-4-(oxiran-2-ylmethoxy)piperidine
• 化学式: C₁₂H₂₃NO₃
• 分子量: 229.32
• InChiKey: YURSRQJLHRSPFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  45.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-Oxyl-2,2,6,6-tetramethyl-4-glycidyloxypiperidine 、 二甲胺 在 水 作用下， 以 水 为溶剂， 反应 16.0h， 以to leave 10 g of the title compound as a red oil的产率得到1-Oxyl-2,2,6,6-tetramethyl-4-(2-hydroxy-3-dimethylaminopropoxy)piperidine
  参考文献：
  名称：

  Inhibition of pulp and paper yellowing using nitroxides, hydroxylamines and other coadditives

  摘要：

  含有木质素的纸浆或纸张，特别是化学机械或热机械纸浆或纸张，在含有有效的阻化胺化合物的稳定剂量时，具有增强的抗黄变性能，该化合物最好是一种亚硝基氧自由基、羟胺或其铵盐。当存在于UV吸收剂、聚合抑制剂、亚硝基酮、荧光增白剂、金属螯合剂、含硫稳定剂、金属盐和二烯化合物的一种或多种共添加剂时，该性能通常会进一步提高。亚硝基氧自由基、羟胺或其盐、苯并三唑或苯并酚UV吸收剂和金属螯合剂的组合特别有效。选定的1-氧基-2,2,6,6-四甲基哌啶-4-醇衍生物和选定的羟胺盐是新化合物，出人意料地有效。

  公开号：

  US06447644B1
• 作为产物：
  描述：

  1,4-二羟基-2,2,6,6-四甲基哌啶 、 环氧氯丙烷 在 四丁基溴化铵 magnesium sulfate 作用下， 以 sodium hydroxide 、 甲苯 为溶剂， 生成 1-Oxyl-2,2,6,6-tetramethyl-4-glycidyloxypiperidine
  参考文献：
  名称：

  Inhibition of pulp and paper yellowing using nitroxides, hydroxylamines and other coadditives

  摘要：

  含有木质素的纸浆或纸张，特别是化学机械或热机械纸浆或纸张，在含有有效的阻化胺化合物的稳定剂量时，具有增强的抗黄变性能，该化合物最好是一种亚硝基氧自由基、羟胺或其铵盐。当存在于UV吸收剂、聚合抑制剂、亚硝基酮、荧光增白剂、金属螯合剂、含硫稳定剂、金属盐和二烯化合物的一种或多种共添加剂时，该性能通常会进一步提高。亚硝基氧自由基、羟胺或其盐、苯并三唑或苯并酚UV吸收剂和金属螯合剂的组合特别有效。选定的1-氧基-2,2,6,6-四甲基哌啶-4-醇衍生物和选定的羟胺盐是新化合物，出人意料地有效。

  公开号：

  US06447644B1

文献信息

• NOVEL COMPOUNDS, FUNCTIONALISED DIOXABOROLANE OR DIOXABORINANE DERIVATIVES, METHOD FOR PREPARING SAME AND USES THEREOF
  申请人：ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS

  公开号：US20200231605A1

  公开（公告）日：2020-07-23

  The invention relates to functionalised dioxaborolane or dioxaborinane derivatives of formula (I), wherein R 1 is covalently bonded to the boron atom by a carbon atom; one of R 2 , R 3 , R′ 3 or R 4 is a radical of formula —X; or one of R 1 , R 2 , R 3 , R′ 3 or R 4 is a radical of formula —X; and X is a functionalised radical. The invention relates to the method for preparing same and the uses thereof.

  该发明涉及公式（I）的功能化二氧硼杂环烷或二氧硼杂环丁烷衍生物，其中R1通过一个碳原子与硼原子共价结合；R2、R3、R′3或R4中的一个是公式—X的基团；或者R1、R2、R3、R′3或R4中的一个是公式—X的基团；X是一个功能化基团。该发明涉及制备该类化合物的方法及其用途。
• SITE-SPECIFIC DYNAMIC NUCLEAR POLARIZATION NMR AGENTS
  申请人：North Carolina State University

  公开号：US20170029377A1

  公开（公告）日：2017-02-02

  Dynamic nuclear polarization (DNP) agents are provided for DNP nuclear magnetic resonance of analytes. The DNP agents can have the structure A-X-L-R, where A is none or an amphiphilic group; X is a coupling group capable of site-specific binding with the analyte or, when A is an amphiphilic group, capable of site-specific binding with the amphiphilic group; L is a bond or a linker group; and R is a poly-radical group. The poly-radical can be a di-radical, a tri-radical, a tetra-radical, or a combination thereof. Methods of NMR measurement of an analyte comprising an NMR-detectable nucleus are provided. The methods can include the steps of providing a frozen sample containing the analyte and a DNP agent; applying radiation having a frequency that excites electron spin transitions in the DNP agent at an intensity to polarize the NMR-detectable nucleus; and detecting a signal from nuclear spin transitions in the NMR-detectable nucleus.

  动态核极化（DNP）试剂可用于分析物的DNP核磁共振。DNP试剂可以具有A-X-L-R结构，其中A为无或含有亲水/疏水性的基团；X为能够与分析物或（当A为亲水/疏水性基团时）能够与亲水/疏水性基团特异结合的耦合基团；L为键或连接基团；R为多自由基基团。多自由基可以是双自由基、三自由基、四自由基或其组合。本文提供了一种包含NMR可检测核的分析物的NMR测量方法。该方法可以包括以下步骤：提供包含分析物和DNP试剂的冰冻样品；施加具有激发DNP试剂中电子自旋跃迁频率的辐射，其强度足以极化NMR可检测核；检测NMR可检测核的核自旋跃迁信号。
• Chlorohydrin and cationic compounds having high affinity for pulp or paper
  申请人：Cunkle T. Glen

  公开号：US20050092452A1

  公开（公告）日：2005-05-05

  Selected chlorohydrin and cationic compounds containing nitroxide or hydroxylamine moieties are effective in stabilizing pulp or paper, especially pulp or paper containing lignin, against yellowing and discoloration due to the adverse effects of light. These compounds are added at various points in the paper-making process, especially at the wet ends, making the need for water soluble or water dispersible materials having high affinity for pulp or paper essential. This performance is often further enhanced by the presence of one or more coadditives selected from the group consisting of the UV absorbers, the polymeric inhibitors, the nitrones, the fluorescent whitening agents and metal chelating agents. Combinations of hydroxylamines or their salts, benzotriazole or benzophenone UV absorbers and a metal chelating agent are particularly effective.

  选择的含氮氧自由基或羟胺基团的氯水合物和阳离子化合物对于稳定纸浆或纸张，特别是含有木质素的纸浆或纸张，抵御光的不良影响导致的黄变和变色非常有效。这些化合物在造纸过程的各个阶段添加，特别是在湿端，需要具有高亲和力的水溶性或水分散材料是必不可少的。这种性能通常通过存在于紫外线吸收剂、聚合物抑制剂、亚硝基、荧光增白剂和金属螯合剂等组中选择一个或多个共添加剂来进一步增强。羟胺或其盐、苯并三唑或苯并酮紫外线吸收剂和金属螯合剂的组合特别有效。
• Derivatives of 1-oxyl-4-hydroxy-2,2,6,6-tetramethylpiperidine
  申请人：Ciba Specialty Chemicals Corporation

  公开号：US06080864A1

  公开（公告）日：2000-06-27

  Selected derivatives of 1-oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine are surprisingly effective as inhibitors to prevent the premature polymerization of acrylic and methacrylic acids, their esters, their amides, vinyl acetate and acrylonitrile in the presence of water. Some of these derivatives are new compounds.

  1-氧化-2,2,6,6-四甲基-4-羟基哌啶的某些衍生物出乎意料地有效，可以作为抑制剂防止丙烯酸、甲基丙烯酸及其酯、酰胺、乙酸乙烯酯和丙烯腈在水存在下的过早聚合。其中一些衍生物是新化合物。
• Derivatives of 1-oxyl-4-hydroxy-2,2,6,6-tetramethylpiperidine as
  申请人：Ciba Specialty Chemicals Corporation

  公开号：US05932735A1

  公开（公告）日：1999-08-03

  Selected derivatives of 1-oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine are surprisingly effective as inhibitors to prevent the premature polymerization of acrylic and methacrylic acids, their esters, their amides, vinyl acetate and acrylonitrile in the presence of water. Some of these derivatives are new compounds.

  1-氧化-2,2,6,6-四甲基-4-羟基哌啶的某些衍生物出人意料地有效，可作为抑制剂防止丙烯酸、甲基丙烯酸、它们的酯、酰胺、醋酸乙烯酯和丙烯腈在水存在下的过早聚合。其中一些衍生物是新化合物。