isopropyl ester of 8-bromooctanoic acid | 1586001-35-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: isopropyl ester of 8-bromooctanoic acid
• 英文别名: 8-bromooctanoic acid isopropyl ester；isopropyl 8-bromooctanoate；Propan-2-yl 8-bromooctanoate；propan-2-yl 8-bromooctanoate
• CAS: 1586001-35-5
• 化学式: C₁₁H₂₁BrO₂
• 分子量: 265.191
• InChiKey: JXGAQJHUGXEYSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  isopropyl ester of 8-bromooctanoic acid 在 lithium hydroxide monohydrate 、 水 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 13.0h， 生成 (R)-6-(tert-butyl)-10-((8-isopropoxy-8-oxooctyl)oxy)-2-oxo-6,7-dihydro-2H-pyrido[2',1':3,4]pyrazino[1,2-b]indazole-3-carboxylic acid
  参考文献：
  名称：

  WO2024077024A2

  摘要：

  公开号：
• 作为产物：
  描述：

  异丙醇 、 8-溴辛酸 在 氯化亚砜 作用下， 以95.91 %的产率得到isopropyl ester of 8-bromooctanoic acid
  参考文献：
  名称：

  WO2024077024A2

  摘要：

  公开号：

文献信息

• Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases
  作者：Ramesh Ekambaram、Erki Enkvist、Ganesh babu Manoharan、Mihkel Ugandi、Marje Kasari、Kaido Viht、Stefan Knapp、Olaf-Georg Issinger、Asko Uri

  DOI：10.1039/c3cc49198f

  日期：——

  Benzoselenadiazole was used as a novel scaffold for construction of microsecond scale responsive photoluminescent probes for protein kinases.

  Benzoselenadiazole被用作构建微秒级响应性荧光探针的新型支架，用于蛋白激酶。
• Bisubstrate fluorescent probes for protein kinase CK2
  申请人：University of Tartu

  公开号：US09176064B2

  公开（公告）日：2015-11-03

  This invention relates to fluorescent probes for screening and characterization of compounds binding to protein kinase CK2, measurement of concentration of the catalytically active form of CK2 and imaging of CK2 activity in cells and tissues. The CK2-selective probe of the present invention interacts with binding sites of both substrates of the catalytic subunit of CK2 and therefore can be used for characterization of all inhibitors binding to the active site of CK2 in the binding/displacement assay. The high affinity of the probe affords the detection of the enzyme at low concentration and characterization of inhibitors in a wide affinity range. The invention also relates to the application of the probes for mapping and monitoring of CK2 activity in cells, tissues and live organisms.

  本发明涉及用于筛选和表征与蛋白激酶CK2结合的化合物、测量CK2催化活性形式的浓度以及成像细胞和组织中CK2活性的荧光探针。本发明的CK2选择性探针与CK2催化亚基的两个底物的结合位点相互作用，因此可用于表征所有结合到CK2活性位点的抑制剂在结合/置换试验中的作用。探针的高亲和力可在低浓度下检测酶，并表征广泛亲和力范围内的抑制剂。本发明还涉及将探针应用于细胞、组织和活体中CK2活性的映射和监测。
• Polyhydroxyalkanoate having vinyl group, ester group, carboxyl group, and sulfonic group, and method of producing the same
  申请人：Kenmoku Takashi

  公开号：US20070073006A1

  公开（公告）日：2007-03-29

  To provide a novel polyhydroxyalkanoate having a reactive functional group in a molecule and a method of producing the same; and a novel polyhydroxyalkanoate having a new function obtained by chemically modifying the polyhydroxyalkanoate having a reactive functional group and a method of producing the same. By utilizing a vinyl group of a polyhydroxyalkanoate containing a unit having the vinyl group at a side chain thereof, a polyhydroxyalkanoate containing units having a carboxyl group, an amide group, and a sulfonic group in a molecule is induced.

  提供一种分子中具有反应性功能基团的新型聚羟基脂肪酸酯及其制备方法；以及通过化学修饰具有反应性功能基团的聚羟基脂肪酸酯获得的具有新功能的新型聚羟基脂肪酸酯及其制备方法。通过利用聚羟基脂肪酸酯中含有侧链上乙烯基的单元的乙烯基，诱导聚羟基脂肪酸酯中含有羧基、酰胺基和磺酸基的单元。
• Polyhydroxyalkanoic Acid Having Vinyl, Ester, Carboxyl or Sulfonic Acid Group and Producing Method Therefor
  申请人：Kenmoku Takashi

  公开号：US20080064828A1

  公开（公告）日：2008-03-13

  The invention is to provide a novel polyhydroxyalkanoate having a reactive function group within the molecule and a producing method therefor In a polyhydroxyalkanoate containing a unit having a vinyl group in a side chain, such vinyl group is utilized for deriving a polyhydroxyalkanoate comprising a carboxyl group or a unit having an amide group and a sulfonic acid group.

  本发明旨在提供一种新型聚羟基烷酸酯，其分子内具有反应性功能团，并提供其制备方法。在含有侧链中具有乙烯基团的聚羟基烷酸酯中，利用该乙烯基团来获得含有羧基或含有酰胺基和磺酸基的聚羟基烷酸酯。
• BISUBSTRATE FLUORESCENT PROBES FOR PROTEIN KINASE CK2
  申请人：University of Tartu

  公开号：US20140057291A1

  公开（公告）日：2014-02-27

  This invention relates to fluorescent probes for screening and characterization of compounds binding to protein kinase CK2, measurement of concentration of the catalytically active form of CK2 and imaging of CK2 activity in cells and tissues. The CK2-selective probe of the present invention interacts with binding sites of both substrates of the catalytic subunit of CK2 and therefore can be used for characterization of all inhibitors binding to the active site of CK2 in the binding/displacement assay. The high affinity of the probe affords the detection of the enzyme at low concentration and characterization of inhibitors in a wide affinity range. The invention also relates to the application of the probes for mapping and monitoring of CK2 activity in cells, tissues and live organisms.

  本发明涉及用于筛选和表征结合到蛋白激酶CK2的化合物、测量CK2催化活性形式的浓度以及在细胞和组织中成像CK2活性的荧光探针。本发明的CK2选择性探针与CK2催化亚基的两个底物的结合位点相互作用，因此可用于特征化所有结合到CK2活性位点的抑制剂在结合/置换试验中的作用。探针的高亲和力可在低浓度下检测酶并特征化广泛亲和力范围内的抑制剂。本发明还涉及将探针应用于细胞、组织和活体中CK2活性的映射和监测。