N-benzyl-2-(4-methoxybenzoyl)azetidine | 1198423-21-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-benzyl-2-(4-methoxybenzoyl)azetidine
• CAS: 1198423-21-0
• 化学式: C₁₈H₁₉NO₂
• 分子量: 281.354
• InChiKey: FFIZFAMPTZEDLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.15
• 重原子数：
  21.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  29.54
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  N-benzyl-2-(4-methoxybenzoyl)azetidine 、 亚甲基三苯基膦烷 以 四氢呋喃 为溶剂， 反应 20.0h， 以0.44 g的产率得到N-benzyl-2-(1-(4-methoxyphenyl)vinyl)azetidine
  参考文献：
  名称：

  Selective Synthesis of Eight-Membered Cyclic Ureas by the [6 + 2] Cycloaddition Reaction of 2-Vinylazetidines and Electron-Deficient Isocyanates

  摘要：

  The [6 + 2] cycloaddition reaction of 2-vinylazetidines with electron-deficient isocyanates such as tosyl Isocyanate proceeded smoothly in the absence of the catalyst at room temperature, and various cyclic ureas were isolated in good to high yields. Electron-deficient allenes also reacted with the 2-vinylazetidine, and the corresponding azocine derivatives were isolated.

  DOI：

  10.1021/ol902299p
• 作为产物：
  描述：

  C₁₈H₂₁NO₂ 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 N-benzyl-2-(4-methoxybenzoyl)azetidine
  参考文献：
  名称：

  Selective Synthesis of Eight-Membered Cyclic Ureas by the [6 + 2] Cycloaddition Reaction of 2-Vinylazetidines and Electron-Deficient Isocyanates

  摘要：

  The [6 + 2] cycloaddition reaction of 2-vinylazetidines with electron-deficient isocyanates such as tosyl Isocyanate proceeded smoothly in the absence of the catalyst at room temperature, and various cyclic ureas were isolated in good to high yields. Electron-deficient allenes also reacted with the 2-vinylazetidine, and the corresponding azocine derivatives were isolated.

  DOI：

  10.1021/ol902299p