1-(formylethyl)-2-pyridone | 143706-11-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(formylethyl)-2-pyridone
• 英文别名: 3-(2-oxopyridin-1(2H)-yl)propanal；3-(2-Oxopyridin-1-yl)propanal
• CAS: 143706-11-0
• 化学式: C₈H₉NO₂
• 分子量: 151.165
• InChiKey: BWUVOFLFGGFDSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  磷酰基乙酸三乙酯 、 1-(formylethyl)-2-pyridone 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 3.5h， 以61%的产率得到1-<4-(ethoxycarbonyl)-3-trans-butenyl>-2-pyridone
  参考文献：
  名称：

  Intramolecular [2 + 2]photocycloadditions of 1-(.omega.-alkenyl)-2-pyridones possessing an ester group on the olefinic carbon chain

  摘要：

  Photochemical reactions of three kinds of 1-(omega-alkenyl)-2-pyridones 1-8 were investigated. Photosensitized cycloadditions of 1-(omega-alkenyl)-2-pyridones and 1,3-bis(omega-alkenyl)-2-pyridone 2-6 afforded intramolecutar [2 + 2]cycloadducts across the 5,6-bonds of the 2-pyridones to give the tricyclic lactams 14-18: the additions were site-, regio-, and stereospecific. The yields of the adducts diminished in proportion to increased side-chain length. The one possessing the shortest alkenyl group, 1, and the 1-[omega-(acryloyloxy)alkyl]-2-pyridones 7 and 8, however, gave no products. On the other hand, direct irradiation of 3 afforded a bicyclic lactam 19. The intramolecular cycloaddition mechanism was discussed in terms of the excited state of 2-pyridone, as calculated by the MNDO-CI method.

  DOI：

  10.1021/jo00047a025
• 作为产物：
  描述：

  2-羟基吡啶 、 丙烯醛 以 苯 为溶剂， 反应 22.0h， 以95%的产率得到1-(formylethyl)-2-pyridone
  参考文献：
  名称：

  Intramolecular [2 + 2]photocycloadditions of 1-(.omega.-alkenyl)-2-pyridones possessing an ester group on the olefinic carbon chain

  摘要：

  Photochemical reactions of three kinds of 1-(omega-alkenyl)-2-pyridones 1-8 were investigated. Photosensitized cycloadditions of 1-(omega-alkenyl)-2-pyridones and 1,3-bis(omega-alkenyl)-2-pyridone 2-6 afforded intramolecutar [2 + 2]cycloadducts across the 5,6-bonds of the 2-pyridones to give the tricyclic lactams 14-18: the additions were site-, regio-, and stereospecific. The yields of the adducts diminished in proportion to increased side-chain length. The one possessing the shortest alkenyl group, 1, and the 1-[omega-(acryloyloxy)alkyl]-2-pyridones 7 and 8, however, gave no products. On the other hand, direct irradiation of 3 afforded a bicyclic lactam 19. The intramolecular cycloaddition mechanism was discussed in terms of the excited state of 2-pyridone, as calculated by the MNDO-CI method.

  DOI：

  10.1021/jo00047a025

文献信息

• Tetrahydro-imidazo quinoline compositions as CBP/P300 inhibitors
  申请人：FORMA Therapeutics, Inc.

  公开号：US11292791B2

  公开（公告）日：2022-04-05

  The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.

  本公开涉及 CBP/p300 系列溴结构域的抑制剂。这些化合物可用于治疗与抑制 CBP/p300 家族溴结构域相关的疾病或紊乱。例如，本公开涉及用于抑制 CBP/p300 家族溴基链的化合物和组合物，治疗、预防或改善与抑制 CBP/p300 家族溴基链相关的疾病或紊乱的方法，以及合成这些化合物的方法。
• TETRAHYDRO-IMIDAZO QUINOLINE COMPOSITIONS AS CBP/P300 INHIBITORS
  申请人：FORMA Therapeutics, Inc.

  公开号：US20200216445A1

  公开（公告）日：2020-07-09

  The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.
• Intramolecular [2 + 2]photocycloadditions of 1-(.omega.-alkenyl)-2-pyridones possessing an ester group on the olefinic carbon chain
  作者：Kenichi Somekawa、Hiroyuki Okuhira、Masayuki Sendayama、Takaaki Suishu、Tetsuro Shimo

  DOI：10.1021/jo00047a025

  日期：1992.10

  Photochemical reactions of three kinds of 1-(omega-alkenyl)-2-pyridones 1-8 were investigated. Photosensitized cycloadditions of 1-(omega-alkenyl)-2-pyridones and 1,3-bis(omega-alkenyl)-2-pyridone 2-6 afforded intramolecutar [2 + 2]cycloadducts across the 5,6-bonds of the 2-pyridones to give the tricyclic lactams 14-18: the additions were site-, regio-, and stereospecific. The yields of the adducts diminished in proportion to increased side-chain length. The one possessing the shortest alkenyl group, 1, and the 1-[omega-(acryloyloxy)alkyl]-2-pyridones 7 and 8, however, gave no products. On the other hand, direct irradiation of 3 afforded a bicyclic lactam 19. The intramolecular cycloaddition mechanism was discussed in terms of the excited state of 2-pyridone, as calculated by the MNDO-CI method.