(2-bromoethyl)-(6-fluorobenzothiazol-2-yl)amine | 1418191-26-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: (2-bromoethyl)-(6-fluorobenzothiazol-2-yl)amine
• 英文别名: N-(2-bromoethyl)-6-fluoro-1,3-benzothiazol-2-amine
• CAS: 1418191-26-0
• 化学式: C₉H₈BrFN₂S
• 分子量: 275.144
• InChiKey: CENFOWJCMLNFEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  53.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(4-氟苯基)-2-硫脲 在 氨 、 溴 、 potassium carbonate 作用下， 以 乙醇 、 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 22.25h， 生成 (2-bromoethyl)-(6-fluorobenzothiazol-2-yl)amine
  参考文献：
  名称：

  Synthesis, cytotoxic evaluation, and in silico studies of substituted N-alkylbromo-benzothiazoles

  摘要：

  In efforts to develop a new class of anticancer agents with improved efficacy and selective action, a series of N-alkylbromo-benzothiazoles were synthesized and evaluated for in vitro cytotoxic activity against various human cancer cell lines such as lung (A-549), prostate (PC-3), leukemia (THP-1), and colon (Caco-2). They were found to be highly active against prostate (PC-3) and leukemia (THP-1) cancer cells, moderately active against colon (Caco-2) cancer cells and less active against lung (A-549) cancer cells. Of the 12 compounds, two (11d, 11j) exhibit IC50 values of a parts per thousand currency sign 1 mu M against leukemia (THP-1) cancer cell lines. Compound 11l showed significant cytotoxic activity against the PC-3 (IC50 = 0.6 mu M), THP-1 (IC50 = 3 mu M) and Caco-2 cell lines (IC50 = 9.9 mu M), respectively. Docking study of the synthesized ligand was done on epidermal growth factor receptor using ArgusLab flexible docking, to determine their observed activity. Further QSAR investigations with stepwise multiple linear regression analysis were applied to find correlation between various physicochemical parameters and anticancer activity. The QSAR results showed that anticancer activity could be modeled with descriptors. The predictive ability of models was cross-validated by observation of the low residual activity values and adjusted coefficient of variation () obtained by leave-one-out technique.

  DOI：

  10.1007/s00044-012-0424-0

文献信息

• Synthesis, cytotoxic evaluation, and in silico studies of substituted N-alkylbromo-benzothiazoles
  作者：Rupinder Kaur Gill、Gagandeep Singh、Anuradha Sharma、P. M. S. Bedi、A. K. Saxena

  DOI：10.1007/s00044-012-0424-0

  日期：2013.9

  In efforts to develop a new class of anticancer agents with improved efficacy and selective action, a series of N-alkylbromo-benzothiazoles were synthesized and evaluated for in vitro cytotoxic activity against various human cancer cell lines such as lung (A-549), prostate (PC-3), leukemia (THP-1), and colon (Caco-2). They were found to be highly active against prostate (PC-3) and leukemia (THP-1) cancer cells, moderately active against colon (Caco-2) cancer cells and less active against lung (A-549) cancer cells. Of the 12 compounds, two (11d, 11j) exhibit IC50 values of a parts per thousand currency sign 1 mu M against leukemia (THP-1) cancer cell lines. Compound 11l showed significant cytotoxic activity against the PC-3 (IC50 = 0.6 mu M), THP-1 (IC50 = 3 mu M) and Caco-2 cell lines (IC50 = 9.9 mu M), respectively. Docking study of the synthesized ligand was done on epidermal growth factor receptor using ArgusLab flexible docking, to determine their observed activity. Further QSAR investigations with stepwise multiple linear regression analysis were applied to find correlation between various physicochemical parameters and anticancer activity. The QSAR results showed that anticancer activity could be modeled with descriptors. The predictive ability of models was cross-validated by observation of the low residual activity values and adjusted coefficient of variation () obtained by leave-one-out technique.