1,2-二棕榈酰磷脂酰甘油 | 4537-77-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 中文名称: 1,2-二棕榈酰磷脂酰甘油
• 中文别名: 3-{[(2,3-二羟基丙氧基)(羟基)磷基]氧代}-2-(十六烷基桥氧基)丙基十六烷酸酯；二棕榈酰磷脂酰甘油
• 英文名称: dipalmitoylphosphatidylglycerol
• 英文别名: 1-(1,2-dipalmitoyl-sn-glycerol-3-phospho)-rac-glycerol；1,2-dipalmitoyl-sn-glycero-3-phosphatidylglycerol；1,2-dipalmitoylphosphatidylglycerol；PG(16:0/0:0)；DPPG；dipalmitoyl phosphatidyl glycerol；[3-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-2-hexadecanoyloxypropyl] hexadecanoate
• CAS: 4537-77-3
• 化学式: C₃₈H₇₅O₁₀P
• 分子量: 722.981
• InChiKey: BIABMEZBCHDPBV-UHFFFAOYSA-N

物化性质

• 沸点：
  761.7±70.0 °C(Predicted)
• 密度：
  1.043±0.06 g/cm3(Predicted)
• 碰撞截面：
  263.91 Ų [M-H]- [CCS Type: TW, Method: calibrated with phosphatidylcholines (ESI+) and phosphatidylethanolamines (ESI-) doubly charged cardiolipins calibrated with poly-DL-alanine]

计算性质

• 辛醇/水分配系数(LogP)：
  12.2
• 重原子数：
  49
• 可旋转键数：
  40
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  149
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  3,5-双三氟甲基溴苯 、 、 1,2-二棕榈酰磷脂酰甘油 、 N-methyl-4-(2-methylphenyl)-2-morpholin-4-ylquinolin-6-amine 在 Na Ot-Bu 、 氮 、 EtOAc hexanes 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 N-[3,5-bis(trifluoromethyl)phenyl]-N-methyl-4-(2-methylphenyl)-2-morpholin-4-ylquinolin-6-amine
  参考文献：
  名称：

  Quinoline Tachykinin Receptor Antagonists

  摘要：

  本发明涉及某些喹啉化合物，其作为神经激肽-1（NK-1）受体拮抗剂和快速激肽，特别是物质P的抑制剂具有用途。本发明还涉及包含这些化合物作为活性成分的制药配方以及在治疗某些疾病，包括呕吐、尿失禁、抑郁症和焦虑症中使用这些化合物和它们的配方。

  公开号：

  US20070293492A1
• 作为产物：
  描述：

  3-(((2,3-bis(benzyloxy)propoxy)(2,2,2-trichloroethoxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate 在 palladium on activated charcoal 吡啶 、 氢气 、 溶剂黄146 、 锌 作用下， 生成 1,2-二棕榈酰磷脂酰甘油
  参考文献：
  名称：

  Lammers,J.G.; van Boom,J.H., Recueil des Travaux Chimiques des Pays-Bas, 1979, vol. 98, p. 243 - 250

  摘要：

  DOI：
• 作为试剂：
  描述：

  N-methyl-4-(2-methylphenyl)-2-morpholin-4-ylquinolin-6-amine 、 3,5-双三氟甲基溴苯 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 1,2-二棕榈酰磷脂酰甘油 sodium t-butanolate 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 N-[3,5-bis(trifluoromethyl)phenyl]-N-methyl-4-(2-methylphenyl)-2-morpholin-4-ylquinolin-6-amine
  参考文献：
  名称：

  WO2006/60390

  摘要：

  公开号：

文献信息

• Use of particulate contrast agents in diagnostic imaging for studying physiological paramaters
  申请人：Fossheim Lise Sigrid

  公开号：US20050136002A1

  公开（公告）日：2005-06-23

  The present invention relates to a method of imaging of an animate human or non-human animal body, which method comprises: administering parenterally to said body a particulate material comprising a matrix or membrane material and at least one contrast generating species, which matrix or membrane material is responsive to a pre-selected physiological parameter whereby to alter the contrast efficacy of said species in response to a change in the value of said parameter; generating image data of at least part of said body in which said species is present; and generating therefrom a signal indicative of the value or variation of said parameter in said part of said body. The invention also relates to contrast media for imaging a physioloogical parameter.

  本发明涉及一种用于成像活体人类或非人类动物体的方法，该方法包括：将包含基质或膜材料和至少一种对比产生物的颗粒材料经肠外途径注入到该体内，其中所述基质或膜材料对预选生理参数具有响应性，以便在所述参数值发生变化时改变所述物种的对比效能；在存在所述物种的至少一部分体内生成图像数据；并从中生成一个信号，该信号指示所述部位体内所述参数的值或变化。本发明还涉及用于成像生理参数的对比介质。
• Liposome-enhanced immunoassay and test device
  申请人：Cornell Research Foundation, Inc.

  公开号：US05789154A1

  公开（公告）日：1998-08-04

  A test device for detecting or determining an analyte in a test solution includes an absorbent material having separate contact, competitive binding, and measurement portions. The contact portion is positioned for contact with and uptake of the test solution. The competitive binding portion has a binding material for the analyte non-diffusively bound thereto. The measurement portion has a receptor for the analyte and marker-encapsulating liposomes non-diffusively bound thereto. In a method for using the test device, a solution containing the analyte and the analyte-liposome conjugate is allowed to traverse the absorbent material from the contact portion through the competitive binding portion and on through the measurement portion of the absorbent material. The amount of marker in the measurement portion of the absorbent material, following traversal by the test solution, is then determined as a measure of the analyte in the sample. Liposomes encapsulating an electroactive marker are used in conjunction with a test device as described above but which includes an electrochemical measurement portion in place of the measurement portion described above. Test devices and methods employing electrochemical detection or quantification of an electroactive marker corresponding to the amount of analyte in a sample may be either amperometric or potentiometric.

  用于检测或确定测试溶液中分析物的测试装置包括具有分离接触、竞争结合和测量部分的吸收材料。接触部分位于与测试溶液接触并吸收测试溶液的位置。竞争结合部分具有结合分析物的结合材料，不可扩散地结合在其上。测量部分具有分析物的受体和包含标记物的脂质体，不可扩散地结合在其上。在使用测试装置的方法中，允许包含分析物和分析物-脂质体共轭物的溶液从接触部分开始穿过吸收材料，经过竞争结合部分并穿过吸收材料的测量部分。然后测量吸收材料中测量部分的标记物的量，作为样品中分析物的测量值。在上述测试装置中，使用包含电活性标记物的脂质体，但将测量部分替换为电化学测量部分。使用电化学检测或定量与样品中分析物量相对应的电活性标记物的测试装置和方法可以是电流计或电位计。
• Liposome enhanced immunoaggregation assay and test device
  申请人：Cornell Research Foundation, Inc.

  公开号：US06086748A1

  公开（公告）日：2000-07-11

  A test device for detecting or quantifying an analyte in a test sample includes an absorbent material having separate contact and measurement portions. The contact portion is positioned at or proximate to a first end of the absorbent material. The measurement portion has a receptor for a conjugate of an analyte analog and marker-encapsulating liposomes. In a method for using the test device, a binding material specific for the analyte is combined with the liposome-analyte analog conjugate and the test sample to form a test mixture. The mixture is incubated for a time sufficient to permit competition between any analyte present and the conjugate for the binding material. Following incubation, the mixture is allowed to traverse the absorbent material from the contact portion through the measurement portion of the absorbent material. Following traversal by the test mixture, the presence or amount of marker in the measurement portion of the absorbent material is then detected and correlated with the presence or amount, respectively, of the analyte in the sample. Liposomes encapsulating an electroactive marker are used in conjunction with a test device as described above but which includes an electrochemical measurement portion in place of the measurement portion described above. Test devices and methods employing electrochemical detection or quantification of an electroactive marker corresponding to the amount of analyte in a sample may be either amperometric or potentiometric.

  一种检测或定量测试样品中分析物的测试装置，包括具有分离接触和测量部分的吸收材料。接触部分位于吸收材料的第一端或靠近第一端。测量部分具有分析物类似物和标记封装脂质体的结合物的受体。在使用测试装置的方法中，将特异于分析物的结合材料与脂质体 - 分析物类似物结合物和测试样品结合形成测试混合物。混合物孵育一段足够的时间以允许任何存在的分析物与结合材料竞争。孵育后，允许混合物从接触部分穿过吸收材料到达吸收材料的测量部分。穿过测试混合物后，检测吸收材料的测量部分中的标记的存在或数量，并将其与样品中的分析物的存在或数量相对应。封装电活性标记的脂质体与上述测试装置一起使用，但是在上述测量部分的位置上包括电化学测量部分。使用电化学检测或定量电活性标记对应于样品中分析物量的测试装置和方法可以是安培计或电位计。
• USE OF PARTICULATE CONTRAST AGENTS IN DIAGNOSTIC IMAGING FOR STUDYING PHYSIOLOGICAL PARAMATERS
  申请人：Fossheim Sigrid Lise

  公开号：US20090191131A1

  公开（公告）日：2009-07-30

  The present invention relates to a method of imaging of an animate human or non-human animal body, which method comprises: administering parenterally to said body a particulate material comprising a matrix or membrane material and at least one contrast generating species, which matrix or membrane material is responsive to a pre-selected physiological parameter whereby to alter the contrast efficacy of said species in response to a change in the value of said parameter; generating image data of at least part of said body in which said species is present; and generating therefrom a signal indicative of the value or variation of said parameter in said part of said body. The invention also relates to contrast media for imaging a physiological parameter.

  本发明涉及一种成像动物或非人类动物体的方法，该方法包括：将包含基质或膜材料和至少一种对比剂的颗粒状物质经肠外给予该体，该基质或膜材料对预选生理参数具有响应性，以便在该参数值发生变化时改变该对比剂的对比效果；生成至少该体的部分中存在该对比剂的图像数据；并由此生成一个信号，指示该体部分中该参数的值或变化。本发明还涉及用于成像生理参数的对比介质。
• Stepanov, A. E.; Makarova, I. M.; Shvets, V. I., Journal of Organic Chemistry USSR (English Translation), 1984, p. 896 - 899
  作者：Stepanov, A. E.、Makarova, I. M.、Shvets, V. I.

  DOI：——

  日期：——