2-acetyl-6-(trimethylstannyl)pyridine | 874379-31-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-acetyl-6-(trimethylstannyl)pyridine
• 英文别名: 1-(6-Trimethylstannylpyridin-2-yl)ethanone
• CAS: 874379-31-4
• 化学式: C₁₀H₁₅NOSn
• 分子量: 283.945
• InChiKey: ZECOZMRTVQUCBV-UHFFFAOYSA-N

物化性质

• 沸点：
  298.2±50.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.83
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-acetyl-6-(trimethylstannyl)pyridine 在 四(三苯基膦)钯 氢氧化钾 作用下， 以 乙二醇二甲醚 、 乙醇 为溶剂， 反应 72.0h， 生成 3,6-di[6-(1,10-phenanthrolin-2-yl)pyrid-2-yl]pyridazine
  参考文献：
  名称：

  Synthetic Approaches to Polypyridyl Bridging Ligands with Proximal Multidentate Binding Sites

  摘要：

  A series of 12 bridging ligands was prepared. These ligands include a central linker appended to two 1,8-naphthyrid-2-yl or two 1,10-phenanthrolin-2-yl units. The linkers include pyridazin-3.6-diyl, 1,8-naphthyrid-2,7-diyl, 2,2'-bipyrid-6,6'-diyl, 1, 10-phenanthrolin-2,9-diyl, 1,2-di(2'-pyrid-6'-yl)ethyne, and 3,6-di(2'-pyrid-6'-yl)pyridazine. The ligands were synthesized from the diacetyl derivative of the central linker by a Friedlander condensation with either 2-aminonicotinaldehyde or 8-amino-7-quinolinecarbaldehyde. The precursor diacetyl derivatives were, in turn, prepared by pathways involving Stille and Sonogashira couplings. Examination of the electronic absorption spectra of the bridging ligands shows the strongest correlation to be between pairs of ligands having the same central linker. Complexation studies will follow.

  DOI：

  10.1021/jo051937r
• 作为产物：
  描述：

  2,6-二溴吡啶 在 四(三苯基膦)钯 正丁基锂 作用下， 以 乙二醇二甲醚 、 乙醚 、 正己烷 为溶剂， 反应 114.0h， 生成 2-acetyl-6-(trimethylstannyl)pyridine
  参考文献：
  名称：

  Synthetic Approaches to Polypyridyl Bridging Ligands with Proximal Multidentate Binding Sites

  摘要：

  A series of 12 bridging ligands was prepared. These ligands include a central linker appended to two 1,8-naphthyrid-2-yl or two 1,10-phenanthrolin-2-yl units. The linkers include pyridazin-3.6-diyl, 1,8-naphthyrid-2,7-diyl, 2,2'-bipyrid-6,6'-diyl, 1, 10-phenanthrolin-2,9-diyl, 1,2-di(2'-pyrid-6'-yl)ethyne, and 3,6-di(2'-pyrid-6'-yl)pyridazine. The ligands were synthesized from the diacetyl derivative of the central linker by a Friedlander condensation with either 2-aminonicotinaldehyde or 8-amino-7-quinolinecarbaldehyde. The precursor diacetyl derivatives were, in turn, prepared by pathways involving Stille and Sonogashira couplings. Examination of the electronic absorption spectra of the bridging ligands shows the strongest correlation to be between pairs of ligands having the same central linker. Complexation studies will follow.

  DOI：

  10.1021/jo051937r

文献信息

• p38α-MK2抑制剂化合物、药物组合物及其应用
  申请人：[en]CHANGCHUN GENESCIENCE PHARMACEUTICAL CO., LTD.;[zh]长春金赛药业有限责任公司

  公开号：WO2024046327A1

  公开（公告）日：2024-03-07

  一种式I所示的化合物、其消旋体、立体异构体、互变异构体、同位素标记物、氮氧化物、溶剂化物、多晶型物、药学上可接受的盐或其前药。该类化合物具有良好的p38α-MK2抑制作用，可用于治疗或预防与p38α-MK2相关的病症和疾病，以及制备用于治疗或预防此类病症和疾病的药物。