3-p-methoxyphenyl-2-methyl-4,5,5-trifluoro-4-trifluoromethyl-isoxazolidine | 1040354-89-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-p-methoxyphenyl-2-methyl-4,5,5-trifluoro-4-trifluoromethyl-isoxazolidine
• 英文别名: 4,5,5-Trifluoro-3-(4-methoxyphenyl)-2-methyl-4-(trifluoromethyl)-1,2-oxazolidine
• CAS: 1040354-89-9
• 化学式: C₁₂H₁₁F₆NO₂
• 分子量: 315.215
• InChiKey: MXCZGAQDVUMTGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  3-p-methoxyphenyl-2-methyl-4,5,5-trifluoro-4-trifluoromethyl-isoxazolidine 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 1.0h， 生成 1-methyl-4-p-methoxyphenyl-3-fluoro-3-trifluoromethyl-2-azetidinone 、 1-methyl-4-p-methoxyphenyl-3-fluoro-3-trifluoromethyl-2-azetidinone
  参考文献：
  名称：

  Synthesis of α-Trifluoromethyl-β-lactams and Esters of β-Amino Acids via 1,3-Dipolar Cycloaddition of Nitrones to Fluoroalkenes

  摘要：

  Nitrones derived from aromatic or aliphatic aldehydes or ketones react with hexafluoropropene (HFP) or 2H-pentafluoropropene (PFP) to give the respective fluorinated isoxazolidine derivatives in good yields with complete regioselectivity and moderate diastereoselectivity. Catalytic hydrogenolysis of the N-O bond under ambient pressure and temperature leads to fluorides of beta-amino acids that undergo cyclization to alpha-trifluoromethylated beta-lactams or, under acidic conditions, form esters of alpha-trifluoromethylated beta-amino acids.

  DOI：

  10.1021/jo800721w
• 作为产物：
  描述：

  六氟丙烯 、 4-methoxybenzylidenemethylamine N-oxide 以 乙腈 为溶剂， 反应 24.0h， 以87%的产率得到3-p-methoxyphenyl-2-methyl-4,5,5-trifluoro-4-trifluoromethyl-isoxazolidine
  参考文献：
  名称：

  Synthesis of α-Trifluoromethyl-β-lactams and Esters of β-Amino Acids via 1,3-Dipolar Cycloaddition of Nitrones to Fluoroalkenes

  摘要：

  Nitrones derived from aromatic or aliphatic aldehydes or ketones react with hexafluoropropene (HFP) or 2H-pentafluoropropene (PFP) to give the respective fluorinated isoxazolidine derivatives in good yields with complete regioselectivity and moderate diastereoselectivity. Catalytic hydrogenolysis of the N-O bond under ambient pressure and temperature leads to fluorides of beta-amino acids that undergo cyclization to alpha-trifluoromethylated beta-lactams or, under acidic conditions, form esters of alpha-trifluoromethylated beta-amino acids.

  DOI：

  10.1021/jo800721w